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GlossaryEctodysplasin A Receptor

protein crucial for hair, teeth, and gland development

The Ectodysplasin A Receptor (EDAR) is a protein that plays a crucial role in the development of hair, teeth, and certain glands. Mutations in the EDAR gene can lead to conditions like hypohidrotic ectodermal dysplasia, which is characterized by sparse hair, missing teeth, and reduced ability to sweat.

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Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor

4 citations , July 2020 in “Biochemical and Biophysical Research Communications”

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

research Epidermal patterning and induction of different hair types during mouse embryonic development

81 citations , September 2009 in “Birth defects research”

Different body areas in mice produce different hair types due to interactions between skin layers.

research Lgr5 Stem Cells and Potential Treatments for Hair Loss

January 2026 in “Theoretical and Natural Science”

Targeting Lgr5+ stem cells and Wnt signaling may effectively treat hair loss.

research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

Certain RNA molecules are important for the development of wool follicles in sheep.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

Faculty Opinions Recommendation of Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

research Faculty Opinions recommendation of Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss.

January 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The research found that certain genes are linked to male pattern baldness, but these same genes do not affect female pattern hair loss.

research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

48 citations , January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Chemokine signaling is important for hair development.

research p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss

37 citations , April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form

research Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form

98 citations , June 2008 in “Human mutation”

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness

research Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness

42 citations , April 2009 in “Human Genetics”

A specific genetic mutation may increase male pattern baldness risk, especially in Europeans.

research Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes

117 citations , April 2008 in “Developmental biology”

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

research Ectodysplasin research—Where to next?

30 citations , June 2014 in “Seminars in Immunology”

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

research Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

43 citations , February 2013 in “Developmental dynamics”

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

research XEDAR activates the non-canonical NF-κB pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways

June 2025 in “Preprints.org”

EDA is vital for bone and cartilage formation and could help treat skeletal disorders.

A Replication Study Confirmed the EDAR Gene to Be a Major Contributor to Population Differentiation Regarding Head Hair Thickness in Asia

research A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia

89 citations , August 2008 in “Human genetics”

The EDAR gene greatly affects hair thickness in Asian populations.

EDA and EDAR Expression at Different Stages of Hair Follicle Development in Cashmere Goats and Effects on Expression of Related Genes

research EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes

12 citations , December 2020 in “Archives animal breeding/Archiv für Tierzucht”

EDA and EDAR are important for hair follicle development in cashmere goats and affect other related genes.

Transcriptome Sequencing Reveals the Expression Profiles of lncRNAs and mRNAs in Goat Skin Tissues With Different Types of Wool Coats

research Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats

1 citations , May 2025 in “Scientific Reports”

The study identified key genes and pathways that influence goat wool quality and growth.

Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves

research Feather arrays are patterned by interacting signalling and cell density waves

133 citations , February 2019 in “PLoS Biology”

Feather patterns in birds are shaped by signaling interactions and cell movements, with EDA/EDAR crucial for pattern formation.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research TNF superfamily in skin appendage development

86 citations , May 2008 in “Cytokine & growth factor reviews”

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

research The biology of hair diversity

47 citations , January 2013 in “International Journal of Cosmetic Science”

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies

15 citations , June 2020 in “Experimental Dermatology”

Hormones and genes affect hair growth and male baldness.

research Ancient lineages of the keratin-associated protein (KRTAP) genes and their co- option in the evolution of the hair follicle

November 2022 in “Research Square (Research Square)”

Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

Label Retaining Cells with Myoepithelial Characteristics from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

research Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

36 citations , September 2013 in “PLoS ONE”

Sweat gland stem cells help maintain glands, aid wound healing, and can regenerate skin structures.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.