research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation
N-WASP is essential for healthy skin and preventing inflammation.
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810-840 / 1000+ results research The roles of activins in repair processes of the skin and the brain
Activin A helps heal skin wounds and protects the brain after injury.
research JAK inhibition decreases the autoimmune burden in Down syndrome
JAK inhibition may help manage autoimmune conditions in Down syndrome.
research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis
PX-12 may help treat psoriasis by blocking inflammation and cell death.
research Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions
Increasing PDCD4 protein may help prevent or treat some skin cancers.
research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex
Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling
Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.
research Faculty Opinions recommendation of Dermal sheath contraction powers stem cell niche relocation during hair cycle regression.
The dermal sheath's contraction is crucial for hair follicle regression and stem cell relocation.
research Effects of dobutamine on cyclic AMP accumulation induced by the stimulation of dopamine receptors in rabbit retina in vitro
Dobutamine does not mimic dopamine at therapeutic doses but may at very high concentrations; microfilaments, not microtubules, are important for wound healing in Xenopus embryos.
research Yin and yang of hair cells
Activin A increases inner ear hair cell development, while follistatin decreases it.
research EMATOPOIESIS REVOLVES AROUND THE PRIMORDIALEVOLUTIONAL RHYTHM OF INNATE IMMUNITY AND PURINERGIC SIGNALING – A JOURNEY TO THE DEVELOPMENTAL ROOTS
Ancient immune and signaling pathways still regulate blood cell development.
research Synergistic effect of carbodiimide and dehydrothermal crosslinking on acellular dermal matrix
Combining DHT and EDC improves the strength and stability of PADM scaffolds for tissue engineering.
research Atrichia with papular lesions
Accurate diagnosis of APL is crucial to avoid unnecessary treatments.
research p63: a crucial player in epithelial stemness regulation
p63 is essential for controlling epithelial stem cells and tissue health.
research Citrullination at the Inflammatory Skin Barrier
A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.
research LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy
The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.
research Hypotrichosis and nail dysplasia: A novel hidrotic ectodermal dysplasia
A 3-year-old girl has a rare condition causing sparse hair and nail issues, with minimal improvement from treatment.
research 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells
Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.
research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
Edar signaling is crucial for controlling hair growth and regression.
research Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)
The new composite scaffold may effectively treat chronic and deep wounds.
research Development and Maintenance of Epidermal Stem Cells in Skin Adnexa
Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.
research Trans glutaminase-mediated cross-linking in mammalian epidermis
research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity
Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.
research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling
Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.
research A Multimodal Approach to Augmenting Wound Healing: Progress Toward Dermal Regeneration in Mammals
DPCs and new biomaterials can greatly improve skin healing.
research 013 Prostaglandin D2 enhances testosterone metabolism by ROS-mediated altered redox potential in keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.
research Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Hydrogel scaffolds can help wounds heal better and grow hair.
research 1442 Neurotransmitter signaling specify sweat gland stem cell fate through intracellular calcium regulation
PRP can improve hair growth in people with hair loss, but more research is needed.
research The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells.
PDGF and its receptors are crucial for stem cell growth and function.