51 citations
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December 2017 in “Skin Appendage Disorders” Stress may trigger hair loss by affecting immune protection in hair follicles.
6 citations
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November 2022 in “Antioxidants” OR2AT4 helps reduce aging and cell damage in human skin cells.
November 2022 in “Regenerative Therapy” Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.
22 citations
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June 2020 in “iScience” Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.
1 citations
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April 2008 in “Pigment Cell & Melanoma Research” Foxn1 is essential for hair pigmentation by directing pigment transfer to hair cells.
130 citations
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December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle melanocytes die during hair regression.
46 citations
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May 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Significant progress was made in understanding PXE, but effective treatments are still needed.
1 citations
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April 2023 in “Science Advances” High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.
1 citations
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August 2015 in “Experimental Dermatology” KIT's role in skin cells is not entirely independent, as other cells can influence its function.
333 citations
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March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
128 citations
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October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
April 2019 in “Journal of the Endocrine Society” A chest X-ray can effectively diagnose ectopic ACTH secretion from lung tumors.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
292 citations
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April 2024 in “Nature Reviews Disease Primers” Early diagnosis and treatment of PCOS are crucial to reduce health risks and costs.
286 citations
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August 2007 in “Journal of Clinical Investigation” Alopecia areata is an autoimmune disease where T cells attack hair follicles.
171 citations
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June 2004 in “Journal of Investigative Dermatology” GLI2 activates GLI1, promoting skin tumor growth and hair development.
81 citations
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September 2009 in “Birth defects research” Different body areas in mice produce different hair types due to interactions between skin layers.
75 citations
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September 2015 in “Acta biomaterialia” Alkylation of human hair keratin allows for adjustable drug release rates in hydrogels for medical use.
51 citations
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April 2013 in “Journal of Investigative Dermatology” Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.
45 citations
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May 2024 in “International Journal of Molecular Sciences” Alopecia areata is caused by immune attacks on hair follicles, affecting hair growth and quality of life.
45 citations
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August 2023 in “Trends in Cell Biology” Controlling cellular changes can enable safe rejuvenation without cancer risk.
29 citations
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February 2001 in “Proceedings of the National Academy of Sciences” A specific DNA region controls skin cell gene expression by working with certain proteins.
21 citations
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April 2025 in “MedComm” Alopecia areata causes unpredictable hair loss, and more research is needed to fully understand and treat it effectively.
21 citations
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July 2018 in “International Journal of Molecular Sciences” Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.
16 citations
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February 2022 in “Science Advances” Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
14 citations
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February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
6 citations
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January 2015 in “Journal of regenerative medicine & tissue engineering” The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.
5 citations
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April 2022 in “Frontiers in Medicine” Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.
5 citations
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March 2022 in “Frontiers in Medicine” PRP is effective for treating hair loss, especially with other treatments.