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Mutations in the AP1B1 gene cause a new syndrome with skin, hearing, and developmental issues.

Ancient immune and signaling pathways still regulate blood cell development.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

A new ARID1B gene variation causes Coffin-Siris syndrome 1 and early high myopia in a Chinese family.

Genetic testing is crucial for diagnosing and managing non-Herlitz junctional epidermolysis bullosa.

The Hedgehog signaling pathway is linked to cancer development, and targeting it with inhibitors shows promise but faces challenges like resistance.

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.

Prostaglandin E2 helps prevent hair loss from radiotherapy by protecting hair growth cells and aiding self-repair.

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.

Oleoylethanolamide (OEA) safely boosts fat production in skin cells and may help treat dry skin and reduce inflammation.

AMT® is effective and safe for early-stage knee osteoarthritis.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

New SRD5A2 variants may disrupt protein function, aiding diagnosis and treatment of related disorders.

Certain genetic variants in ERN1, TACR3, and SPPL2C are linked to when Alzheimer's disease starts.

Erythrocyte-anchored nanoparticles improved Cepharanthine delivery and effectiveness for treating acute lung injury.

Extramammary Paget disease can spread deeply into tissues, reaching up to 3.6 mm.

PRP injections improve knee function in osteoarthritis.

SSEA-4 can distinguish between eccrine and apocrine sweat gland ducts.

Targeting androgen receptor signaling may improve acute myeloid leukemia treatment.

5α-reductases increase epitestosterone's effect on androgen receptors.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

The over-the-counter supplement DHEA could make COVID-19 worse, especially in diabetics and people with G6PD deficiency.

ERK activation spreads between cells, influencing cell division and wound healing.

Rezpegaldesleukin shows promise for treating severe alopecia areata.

A woman got a skin rash from taking aceclofenac, which went away after she stopped the drug.