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GlossaryEGFR Signaling

EGFR signaling refers to the pathway activated by the epidermal growth factor receptor (EGFR), a cell surface protein that plays a crucial role in cell proliferation, differentiation, and survival. In the context of hair biology, EGFR signaling is significant as it influences hair follicle development and cycling, particularly in the anagen (growth) phase. Dysregulation of this pathway can contribute to hair loss conditions, such as androgenetic alopecia, by affecting the health and function of hair follicles. Key distinguishing characteristics of EGFR signaling include its involvement in various cellular processes and its potential as a therapeutic target for hair restoration treatments.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

41 citations , December 2019 in “Science Translational Medicine”

Anti-EGFR therapy can cause skin issues, but FGF7 treatment might help.

research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

Mathematical modeling helps understand and predict the MAPK cell signaling pathway.

research Epimorphin and Epithelial Morphogenesis

January 2007

Epimorphin helps shape and develop epithelial cells, like those in hair follicles.

research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis

6 citations , December 2019 in “Frontiers in genetics”

GLI1 might protect against the start of skin cancer and is not linked to cancer severity.

research Basal cell carcinoma — molecular biology and potential new therapies

146 citations , February 2012 in “Journal of Clinical Investigation”

Blocking Hedgehog signaling offers new treatment options for advanced basal cell carcinoma.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

research 329 Mechanisms of Cutaneous Adverse Events during Targeted Cancer Therapy

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Targeted cancer therapies can cause skin side effects, but activating SOS in the skin may help reduce them.

research 546 Epidermal growth factor receptor as a key regulator of the immune privilege

November 2022 in “Journal of Investigative Dermatology”

EGFR is crucial for preventing hair follicle inflammation and hair loss.

research Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway

5 citations , October 2024 in “International Journal of Molecular Sciences”

Piperonylic acid may help hair growth and treat hair loss.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway

10 citations , May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling

151 citations , August 2011 in “The EMBO Journal”

The enzyme PA-PLA1α is important for proper hair follicle development.

Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades

research Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

14 citations , January 2016 in “Biochemical and Biophysical Research Communications”

Ginsenoside Re from ginseng may help hair grow by blocking a specific growth-inhibiting pathway.

Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

research Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

December 2025

Platycladi Cacumen may help treat hair loss by targeting specific proteins and pathways.

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

research A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

1 citations , November 2023 in “iScience”

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

research Transient stimulation of TRPV4‐expressing keratinocytes promotes hair follicle regeneration in mice

4 citations , June 2020 in “British Journal of Pharmacology”

Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

research TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

9 citations , January 2015 in “Medical hypotheses”

TCDD disrupts skin stem cells, causing skin issues like chloracne.

research Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin

December 2025 in “Cells”

Poly-D,L-lactic acid boosts hair growth in aged skin by activating hair follicle stem cells.

research When bugs and drugs conspire: driving acneiform skin toxicity

1 citations , February 2020 in “The Journal of clinical investigation/The journal of clinical investigation”

Certain cancer drugs interact with skin bacteria to cause acne-like rashes.

research Hair Growth-Promoting Effects of Astragalus sinicus Extracts in Human Follicle Dermal Papilla Cells

January 2025 in “Cosmetics”

Astragalus sinicus extracts may help promote hair growth and treat hair loss.

research Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model

October 2024 in “International Journal of Molecular Sciences”

Rosa rugosa extract promotes hair growth and could be a natural treatment for hair loss.

research JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

8 citations , November 2024 in “EMBO Molecular Medicine”

Targeting JAK-STAT1 can reduce inflammation and promote hair growth in conditions linked to EGFR deficiency.

research YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

14 citations , November 2024 in “International Journal of Molecular Sciences”

YAP and TAZ proteins control skin cell growth and repair.

research Novel acquisitions on the immunoprotective roles of the EGF receptor in the skin

19 citations , October 2008 in “Expert Review of Dermatology”

EGF receptor is crucial for skin health and its inhibitors can cause skin rashes.

research Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies

December 2025 in “Biomedicines”

Tyrosine kinase inhibitors for endocrine tumors often cause skin issues, requiring early management and treatment adjustments.

research Amphiregulin in Fibrotic Diseases and Cancer

4 citations , July 2025 in “International Journal of Molecular Sciences”

Targeting amphiregulin may improve treatment for fibrosis and cancer.

research Anticancer activity of cepharanthine on non-small cell lung cancer cells

1 citations , January 2020

Cepharanthine shows promise as a potential lung cancer treatment by effectively killing cancer cells.

research The Role of LncRNAs in Radio- and Chemoresistance of Glioblastoma: Prognostic or Therapeutic?

September 2025 in “Current Oncology”

LncRNAs may help improve brain cancer treatment and diagnosis.