research Localized Epidermolysis Bullosa Simplex (Weber-Cockayne type)
A 15-year-old girl has a skin condition causing blisters on her feet, likely inherited from her family.
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research A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle
Endoglin is important for proper hair growth cycles and stem cell activation in hair follicles.
research Expression of basement membrane components through morphological changes in the hair growth cycle
Fibronectin and other basement membrane components increase during hair growth and decrease during rest.
research Ultrasound-ActivatedGelMA Hydrogel Loaded with MSC-EVsPromotes Functional Regeneration of Skin Vasculature, Nerves, andAppendages
Ultrasound and GelMA hydrogel with stem cell vesicles improve skin healing and regeneration.
research Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects
Using gelatin sponges for deep skin wounds helps bone marrow cells repair tissue without scarring.
research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation
The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
research Tissue Expansion in Cicatricial Alopecia
Tissue expansion is an effective treatment for certain types of hair loss, providing immediate coverage with hair-bearing skin.
research Ultrastructural skin changes in Egyptian mandibuloacral dysplasia patients with p.Arg527Leu LMNA mutation and in their asymptomatic heterozygotic mothers
The LMNA mutation affects skin structure even in asymptomatic carriers.
research The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity
ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
research Monilethrix
A 12-year-old girl was diagnosed with monilethrix, a genetic condition causing fragile, beaded hair that breaks easily, with no effective treatment available.
research Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization
Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.
research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.
The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.
research Case of epidermolytic ichthyosis (bullous congenial ichthyosiform erythroderma) with a novel L157P mutation in KRT10 complicated by hypercalcemia
A man with a rare skin condition and a new gene mutation developed high calcium levels due to his treatment.
research A transient dermal niche and dual epidermal programs underlie sweat gland development
Sweat gland development involves two unique skin cell programs and a temporary skin environment.
research 376 Tsc2 disruption in mesenchymal progenitors regulates hair follicles and TGF beta signaling
Disrupting the Tsc2 gene in certain cells leads to thicker skin, larger hair, and changes in hair growth signaling, which can be partly reversed with specific treatment.
research Elastic tissue in scars and alopecia
The VVG stain effectively differentiates scar tissue from normal skin and helps classify types of permanent alopecia.
research Hair follicle stem cells differentiation into bone cells on collagen scaffold
research Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid
research Nature-skin-based multi-responsive controlled-release electroactive scaffolds for integrated melanoma postoperative relapse prevention and wound therapy
The scaffold effectively prevents melanoma relapse and aids wound healing.
research Modulation of sonic hedgehog, patched and patched-2 expression by epidermal growth factor signaling in mouse hair follicle formation
research Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia
Inhibiting connective tissue sheath contraction may improve hair growth in male pattern baldness.
research Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis
Overexpressing follistatin in mice delays wound healing and reduces scar size.
research 414 A new form of ectodermal dysplasia caused by mutations in TSPEAR
Mutations in the TSPEAR gene cause a new form of ectodermal dysplasia affecting hair and tooth development.
research Lamins in development, tissue maintenance and stress
Lamins are vital for cell survival, organ development, and preventing premature aging.
research 768 Dermal fibroblast expression of lef1 is critical to normal skin and hair development and regenerative wound healing in mice
Lef1 is essential for normal skin, hair growth, and healing wounds in mice.
research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region
Proteolytic enzymes damage hair follicles by detaching stem cells.
research Loose Anagen Syndrome
Loose anagen syndrome causes easy hair shedding in children, often resolving on its own.
research Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis
RXRα is crucial for hair growth and skin cell function.
research Molecular mechanisms of ectodermal dysplasia syndromes
Ectodermal dysplasia syndromes are caused by disruptions in key signaling pathways affecting tooth and hair development.
research Bioengineering Skin Constructs
Future research should focus on making bioengineered skin that completely restores all skin functions.