December 2022 in “Biomedicine” Men with early onset hair loss are more likely to have high uric acid levels.
September 2020 in “Zenodo (CERN European Organization for Nuclear Research)” Reducing Zyxin may help treat hair loss.
Women with androgenetic alopecia have normal levels of most blood steroids and binding proteins, but higher dehydroepiandrosterone. Some also have low "sex hormone-binding globulin" and "corticosteroide-binding globulin" capacity, and high "free androgen index" and "free cortisol index". Diane treatment can normalize these levels and improve hair conditions.
December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)” AKR1C3 could be a treatment target for metabolic issues in PCOS.
100 citations
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September 2017 in “Molecular and Cellular Endocrinology” Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.
98 citations
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July 1983 in “Journal of Steroid Biochemistry” Individuals with this condition often develop male traits and identities at puberty despite being raised as females.
54 citations
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February 1993 in “Endocrine reviews” Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.
24 citations
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October 1994 in “Fertility and Sterility” People with hair loss may have different levels of certain hormones due to changes in hormone processing.
22 citations
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September 2024 in “Human Reproduction Update” Androgen measurement helps diagnose PCOS, but accuracy varies, needing standard methods.
20 citations
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October 2017 in “Clinical Endocrinology” The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.
18 citations
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July 2016 in “Medicine” Wnt/β-catenin and TGF-β pathways affect hair loss, and activating Wnt/β-catenin could be a potential treatment.
11 citations
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January 2013 in “Indian Journal of Endocrinology and Metabolism” A woman with a rare adrenal tumor and hormonal disorder had improved testosterone levels after surgery, but her menstrual irregularities continued.
11 citations
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September 1990 in “Clinical Endocrinology” Girls with prepubertal simple hypertrichosis have higher dihydrotestosterone (DHT) levels.
8 citations
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June 2019 in “Scientific Reports” Increased PPARGC1α relates to hair thinning in common baldness.
7 citations
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September 2024 in “International Journal of Molecular Sciences” PCOS involves high 11-oxygenated androgens and BPA may worsen it, while IH is not inflammatory.
5 citations
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April 2014 in “International Journal of Pediatric Endocrinology” Prepubertal girls with hypertrichosis have more sensitive androgen receptors, leading to increased body hair growth.
3 citations
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November 2022 in “Separations” The method accurately measures seven androgens in plasma and shows different hormone levels in females with acne and obesity.
3 citations
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June 2016 in “Gynecological Endocrinology” Doctors used a special blood sampling technique to diagnose a woman's rare ovarian tumor that was producing male hormones.
December 2025 in “IP Indian Journal of Clinical and Experimental Dermatology” Androgenetic alopecia in males is linked to significant psychological distress, highlighting the need for both mental and dermatological care.
December 2025 in “Journal of Skin and Stem Cell” Patients with androgenetic alopecia often have abnormal lipid levels, so they should be screened and advised on lifestyle changes to prevent heart issues.
November 2025 in “Scientific Reports” Liver disease is linked to hair loss, especially in women and those with unhealthy lifestyles.
February 2024 in “Heliyon” People with androgenetic alopecia have different lipid levels in their blood, which vary between men and women, and may be linked to a higher risk of metabolic syndrome.
November 2022 in “Journal of the Endocrine Society” A woman's masculine features were caused by a rare ovarian tumor that produced male hormones.
Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.
January 2019 in “OpenBU/Boston University Institutional Repository (Boston University)” Women with PCOS often show signs of excess androgens like hirsutism, acne, and alopecia, with variations across ethnic groups.
June 2021 in “Egyptian Journal of Dermatology and Venereology” Psoriasis, acne, and hair loss are linked to unhealthy cholesterol levels, increasing heart disease risk.
August 2020 in “Benha Journal of Applied Sciences” Higher NLR, PLR, and MPV may help diagnose androgenetic alopecia.
July 2015 in “Egyptian Journal of Dermatology and Venereology” People with androgenetic alopecia, both men and women, are more likely to develop heart diseases in the future.
February 2015 in “American journal of medical and biological research” Balding hair follicles have less growth-promoting factors and more inhibitory factors, leading to hair loss.
139 citations
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December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.