research SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.
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research Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure
The nanofiber scaffolds improved skin wound healing by supporting cell growth and tissue repair.
research Epidemiology of skin cancer in the mature patient
Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
research Learning from nudity: lessons from the nude phenotype
The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
research A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle
A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.
research Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin
Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.
research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation
Keratin 16 delays skin maturation and affects skin and hair development in mice.
research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia
Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.
research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
A20 protein is crucial for normal skin and hair development.
research Potential adverse effects of long-term testosterone therapy
Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.
research Drug discovery for alopecia: gone today, hair tomorrow
Topical drugs and near-infrared light therapy show potential for treating alopecia.
research Beyond Expectations
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.
research Age-induced hair greying - the multiple effects of oxidative stress
Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.
research β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain
β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.
research Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors
Fibroblasts can be turned into melanocytes for potential skin treatments.
research Obstructive Sleep Apnea Due to Endogenous Testosterone Production in a Woman
Removing a testosterone-producing tumor cured a woman's sleep apnea and other symptoms.
research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
research Emerging nonmetabolic functions of skin fat
Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
research Wound Healing: A Paradigm for Regeneration
Wound healing insights can improve regenerative medicine.
research Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity
Hair follicle stem cells are controlled by their surrounding environment.
research Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars
Condensed nanofat with fat grafts effectively improves atrophic facial scars.
research Coffee Silverskin: A Review on Potential Cosmetic Applications
Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.
research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
Spermidine may help reduce hair loss and deserves further testing as a treatment.
research The role of lymphocytes in the development and treatment of alopecia areata
Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
research Apoptosis and cutaneous biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Targeting lymphoid-derived IL-17 signaling to delay skin aging
Blocking IL-17 signaling may reduce skin inflammation and delay aging.
research Effects of Nitric Oxide on Skin Burn Wound Healing
Nitric oxide gel helps heal skin burns faster by improving skin growth, hair regrowth, and blood vessel formation.
research AGD1, a class 1 ARF‐GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity
AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.