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GlossaryEpidermal Atrophy

thinning of outer skin layer, making it fragile

Epidermal atrophy refers to the thinning of the outermost layer of the skin, known as the epidermis. This condition can result in the skin becoming more fragile, less elastic, and more prone to injuries and infections. It is often associated with aging, prolonged use of topical corticosteroids, or certain medical conditions like chronic dermatitis.

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Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars

February 2024 in “Australasian journal of dermatology”

Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.

research 575 Senescent atrophic epidermis retains Lrig1+ stem cells and loses Wnt signaling, a phenotype shared with CD44KO mice

2 citations , August 2016 in “Journal of Investigative Dermatology”

research Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.

August 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Overexpression of a specific receptor in mice skin causes skin thinning, early skin barrier formation, eye issues, and hair loss.

research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations , December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

research The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

134 citations , January 2011 in “Development”

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

research Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling

19 citations , September 2019 in “PLOS genetics”

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

research Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing

99 citations , October 2008 in “Journal of Investigative Dermatology”

Mutations in the ST14 gene cause skin and hair issues by disrupting important protein processing.

research Lentiginosis within plaques of linear atrophoderma of Moulin: a twin-spotting phenomenon?

9 citations , July 2010 in “British Journal of Dermatology”

The document suggests a rare skin condition might be caused by a genetic phenomenon.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide

2 citations , November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Sclero-Atrophic Reaction after Botulinum Toxin Injection

April 2016 in “Journal of Clinical Research in Dermatology”

A woman had skin and hair issues after a botulinum toxin injection.

research The Effect of Zinc Sulphate in The Prevention of Radiation-induced Dermatitis

57 citations , January 2004 in “Journal of Radiation Research”

Zinc sulphate may help reduce skin damage from radiation therapy.

research Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases

15 citations , December 2011 in “Journal of the European Academy of Dermatology and Venereology”

Hair loss in systemic lupus erythematosus patients is unique and improves with treatment.

research Is growth hormone a radioprotective agent?

8 citations , February 2006 in “Journal of the European Academy of Dermatology and Venereology”

Growth hormone may protect skin from radiation damage.

research A novel actor in skin biology: the mineralocorticoid receptor

7 citations , October 2015 in “Experimental dermatology”

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

research Changes in murine hair with dietary selenium excess or deficiency

6 citations , March 2011 in “Experimental Dermatology”

Too much or too little selenium in the diet can cause hair loss and graying in mice.

research A clinical and histopathological study of cicatricial alopecia

5 citations , July 2013 in “Our Dermatology Online”

Lichen planopilaris is the most common type of scarring hair loss observed, with a variety of symptoms and tissue changes.

research Lichen planopilaris

5 citations , August 2001 in “International Journal of Dermatology”

A 20-year-old had hair loss and skin issues from lichen planopilaris starting at age 10.

research Occurrence of raspberry gall midge Lasioptera rubi Schrank (Diptera, Cecidomyiidae) in some raspberry cultivars.

4 citations , January 2009 in “Acta agriculturae Serbica”

Selenium imbalance can cause hair loss and skin issues.

research A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma

2 citations , March 2019 in “Veterinary dermatology”

Thymoma in cats can cause hair loss without inflammation.

research Linear morphea alopecia: New trichoscopy findings

2 citations , January 2017 in “International Journal of Trichology”

Trichoscopy can reveal specific hair and scalp changes in linear morphea.

research Lupus cutáneo crónico

January 2024 in “Revista Dermatológica Centro Uraga”

The patient has Chronic Cutaneous Lupus, a skin condition causing plaques and hair loss.

research Comparative histopathological analyses of non-scarring alopecia in systemic lupus erythematosus patients in Lagos Nigeria

March 2023 in “Nigerian Journal of Clinical Practice”

The main difference in hair loss for lupus patients is smaller and fewer sebaceous glands.

research Correspondence

January 1999 in “Journal of the European Academy of Dermatology and Venereology”

RAPK is a rare skin disorder with pigmented spots, mainly on hands and feet, starting in youth.

Dose-Dependent Histopathological and Structural Impact of Chemical Hair Straighteners on Scalp Epithelium and Hair Fibers Using Albino Wistar Rats

research Dose-Dependent Histopathological and Structural Impact of Chemical Hair-Straighteners on Scalp Epithelium and Hair-Fibres Using Albino Wistar Rats

September 2025 in “Sahel Journal of Life Sciences FUDMA”

Chemical hair straighteners can severely damage hair and scalp with repeated use.

research Thyroid hormone action on skin.

24 citations , July 2011 in “PubMed”

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.