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GlossaryEpidermal Differentiation Complex

cluster of genes crucial for skin barrier formation

The Epidermal Differentiation Complex (EDC) is a cluster of genes located on chromosome 1 in humans that play a crucial role in the formation and maintenance of the skin barrier. These genes are responsible for producing proteins that help skin cells mature and form the outermost layer of the skin, which protects the body from environmental damage and prevents water loss.

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research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.

39 citations , January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

research Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis

12 citations , December 2022 in “Frontiers in Bioscience-Landmark”

The role of certain genes in skin cell development may be linked to psoriasis, but the connection is unclear.

research Dynamics and Epigenetics of the Epidermal Differentiation Complex

February 2024 in “Epigenomes”

Epigenetic mechanisms control skin development by regulating gene expression.

The Striatin-Interacting Phosphatase And Kinases Complex Is Important for Skin Epidermal Differentiation and Barrier Formation

research 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The STRIPAK complex is crucial for skin cell organization and creating a functional skin barrier.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations , August 2011 in “Toxicological sciences”

TCDD speeds up skin barrier formation by increasing certain gene expressions.

research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

research The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

research Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development

6 citations , June 2021 in “Developmental biology”

Dermal EZH2 controls skin cell development and hair growth in mice.

research Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dermal EZH2 controls skin cell growth and differentiation in mice.

research Eph/ephrin signaling in epidermal differentiation and disease

42 citations , October 2011 in “Seminars in Cell & Developmental Biology”

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

research p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

p63 controls Satb1 to help skin develop properly.

research Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium

56 citations , July 2004 in “Mechanisms of Development”

Pax9 is crucial for proper tongue surface development and preventing skin-like changes.

research Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales

5 citations , January 2022 in “Scientific reports”

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

research Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

research Author response: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

3 citations , January 2016

NuMA-microtubule interactions are crucial for proper skin structure and hair growth.

research Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation

March 2026 in “Frontiers in Cell and Developmental Biology”

Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.

research Genome-wide association study of skin complex diseases

25 citations , March 2012 in “Journal of Dermatological Science”

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis

research Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis

19 citations , September 2014 in “British Journal of Dermatology”

Minoxidil foam 5% effectively treats hair loss in both frontal and vertex scalp regions.

research Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures

February 2025 in “Animals”

Understanding proteins in skin structures like claws and hair is crucial for future research.

research Convergent evolution has led to the loss of claw proteins in snakes and worm lizards

December 2024 in “Genome Biology and Evolution”

Snakes and worm lizards lost claw proteins due to similar evolutionary changes.

research 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification

April 2016 in “Journal of Investigative Dermatology”

Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

Stem Cells Behind the Barrier: Mechanisms Regulating Epidermal Stem and Progenitor Cell Differentiation

research Stem Cells behind the Barrier

22 citations , June 2013 in “International journal of molecular sciences”

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

research MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

1 citations , July 2023 in “Nature communications”

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

research MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

MOF controls skin development by regulating genes for mitochondria and cilia.

research 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

research In-vivo dedifferentiation of keratinocytes to epidermal stem cells

1 citations , February 2002 in “The Lancet”

Keratinocytes might turn into stem cells, but more research is needed to confirm this.

research Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.

107 citations , June 1997 in “PubMed”

EGFR is essential for normal hair development and follicle differentiation.