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GlossaryEpidermal Growth Factor

stimulates cell growth and healing in skin and hair

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth, proliferation, and differentiation by binding to its receptor, EGFR. It plays a crucial role in the healing of wounds and the regeneration of skin and hair follicles. EGF is often used in skincare products to promote skin repair and reduce signs of aging.

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research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

164 citations , December 1984 in “Proceedings of the National Academy of Sciences”

TCDD reduces EGF receptor activity and causes various developmental changes in animals.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

TCDD reduces EGF receptors in the liver, affecting growth and development.

research 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway

research BFNB Enhances Hair Growth in C57BL/6 Mice through the Induction of EGF and FGF7 Factors and the PI3K-AKT-β-Catenin Pathway

2 citations , July 2023 in “International Journal of Molecular Sciences”

BFNB could be a promising treatment for hair growth.

research 785 Single-cell transcriptomic profile of EGFR-deficient epidermal compartments during folliculitis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGFR deficiency causes significant changes in skin cells and hair follicles.

research Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

7 citations , April 2018 in “Molecular Medicine Reports”

BeauTop helps hair grow by increasing certain growth factors.

Heat-Treated Limosilactobacillus Fermentum LM1020 with Menthol, Salicylic Acid, and Panthenol Promotes Hair Growth and Regulates Scalp Microbiome Balance in Androgenetic Alopecia: A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial

research Heat‐treated Limosilactobacillus fermentumLM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double‐blind, randomized and placebo‐controlled clinical trial

May 2024 in “Journal of cosmetic dermatology”

Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

research The relevance of collagen XVII expression in epidermal differentiation and proliferation

September 2016 in “Journal of dermatological science”

Collagen XVII is crucial for skin cell growth and nail health.

research Successful treatment of epidermal growth factor receptor inhibitor–induced alopecia with doxycycline

6 citations , July 2015 in “JAAD Case Reports”

Doxycycline can effectively treat hair loss caused by EGFR inhibitors.

More Is Not Always Better in Hair Growth Factors: Epidermal Growth Factor Involved in Alopecia Areata Pathogenesis

research More is not always better in hair growth factors. epidermal growth factor: hair growth factor involved in alopecia areata pathogenesis

4 citations , January 2020 in “International Journal of Trichology”

Too much epidermal growth factor can cause hair loss.

research Proangiogenic and Collagen-Promoting Effects of a 70% Ethanol Extract of Grateloupia angusta in Cutaneous Wound Models

March 2026 in “International Journal of Molecular Sciences”

Grateloupia angusta extract helps heal wounds faster and improve skin repair.

research Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

32 citations , April 2011 in “Journal of the American Academy of Dermatology”

Erlotinib may cause scarring hair loss.

research The trichoscopic features of hair shaft anomalies induced by epidermal growth factor receptor inhibitors: A case series

7 citations , March 2020 in “Journal of the American Academy of Dermatology”

EGFR inhibitors often cause dry, brittle hair and eyebrow/eyelash changes.

research Influence of aerosol bioelectricity on expression of epidermal growth factor and β_1 integrin in healing wounds of burned rats

January 2005 in “Di-san junyi daxue xuebao”

Aerosol bioelectricity speeds up wound healing in burned rats.

research Effects of Intradermally Injected and Topically Applied Mouse Epidermal Growth Factor on Wool Growth, Skin and Wool Follicles of Merino Sheep

36 citations , June 1988 in “Australian Journal of Biological Sciences”

Mouse epidermal growth factor injections in sheep affected wool growth and skin, but saline did not.

research Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839

1 citations , March 2004 in “Journal of the American Academy of Dermatology”

ZD1839, a cancer drug, can cause mild skin rashes that are treatable without stopping the medication.

research Safety and quality of life of CDK4/6 inhibitors therapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: a multicenter cross-sectional survey in China

1 citations , May 2025 in “BMC Cancer”

CDK4/6 inhibitors affect safety and quality of life differently, requiring careful use.

research Effect Of Epidermal Growth Factor & Platelet-Rich Plasma In Experimental Rat Burn Model

June 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

PRP and EGF speed up healing in severe rat burns.

research Aplicaciones del plasma rico en plaquetas como terapia en dermatología

January 2016 in “Más dermatología”

Platelet-rich plasma therapy helps heal skin ulcers and stimulates hair growth in dermatology.

research Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

73 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Markers help differentiate between apocrine and eccrine sweat glands to identify sweat gland tumors.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

research Perifollicular Xanthomas Associated with Epidermal Growth Factor Receptor Inhibitor Therapy

17 citations , January 2010 in “Acta Dermato Venereologica”

EGFR inhibitors can cause yellowish skin eruptions.

research LAM/TSC Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis. Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin

2 citations , January 2014 in “Journal of Cytology & Histology”

Rapamycin and anti-EGFR antibody reduce LAM/TSC cell migration and blood vessel growth in the uterus.

research Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion

1 citations , July 2024 in “British Journal of Dermatology”

Inhibiting certain proteins harms hair follicle immunity and increases IL-33, affecting hair health.

research A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex

August 2024 in “Postgraduate Medical Journal”

A rare skin reaction from cancer treatment was successfully managed with topical treatments and antihistamines.

Association Between Epidermal Growth Factor and Epidermal Growth Factor Receptor Gene Polymorphisms and Susceptibility to Alopecia Areata in Korean Population

research Association between epidermal growth factor and epidermal growth factor receptor gene polymorphisms and susceptibility to alopecia areata in Korean population

February 2013 in “Journal of the American Academy of Dermatology”

Certain gene variations might increase the risk of a hair loss condition in Koreans.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

125 citations , February 2007 in “The EMBO Journal”

Fgfr2b helps maintain healthy skin and prevent cancer.

research Immunohistochemical Study on the Hair Growth Promoting Effect of Yonnyuniksoogobon-dan

1 citations , November 2008

Yonnyuniksoogobon-dan taken orally promotes hair growth by affecting growth factors in hair roots.