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GlossaryEpidermal Growth Factor Receptor

protein on cell surfaces aiding growth and division

The Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that helps them grow and divide. It is crucial in regulating cell growth, survival, and differentiation. When EGFR is mutated or overexpressed, it can lead to uncontrolled cell proliferation, which is a common feature in various cancers.

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Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

research Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors

138 citations , February 2007 in “European journal of cancer”

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

research The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome

90 citations , August 2006 in “British Journal of Dermatology”

PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research Dermatological side effects of epidermal growth factor receptor inhibitors: ′Pride′ complex

43 citations , January 2014 in “Indian Journal of Dermatology”

EGFR inhibitors can cause skin issues like acne and dryness, but these can be managed without stopping treatment.

Semiology of Skin Toxicity Associated with Epidermal Growth Factor Receptor Inhibitors

research Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors

38 citations , February 2012 in “Supportive Care in Cancer”

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

research A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

33 citations , June 2009 in “Journal of Cutaneous Pathology”

Erlotinib can cause nonscarring hair loss and itchy skin.

research Perifollicular Xanthomas Associated with Epidermal Growth Factor Receptor Inhibitor Therapy

17 citations , January 2010 in “Acta Dermato Venereologica”

EGFR inhibitors can cause yellowish skin eruptions.

research Histopathologic features of erythematous papulopustular eruption to epidermal growth factor receptor inhibitors in cancer patients

9 citations , October 2015 in “Journal of Cutaneous Pathology”

Erythematous papulopustular eruptions in cancer patients using EGFR inhibitors show specific skin changes that vary with severity and treatment type.

research Epidermal Growth Factor Receptor Inhibitors: Cutaneous Side Effects and Their Management.

9 citations , September 2017 in “PubMed”

EGFR inhibitors can cause skin issues, but managing them is important for treatment success.

research The trichoscopic features of hair shaft anomalies induced by epidermal growth factor receptor inhibitors: A case series

7 citations , March 2020 in “Journal of the American Academy of Dermatology”

EGFR inhibitors often cause dry, brittle hair and eyebrow/eyelash changes.

research Successful treatment of epidermal growth factor receptor inhibitor–induced alopecia with doxycycline

6 citations , July 2015 in “JAAD Case Reports”

Doxycycline can effectively treat hair loss caused by EGFR inhibitors.

research Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege

4 citations , June 2024 in “British Journal of Dermatology”

EGFRi/MEKi treatments cause hair follicles to lose some immune protection, leading to inflammation.

research Epidermal growth factor receptor inhibitors and hair

4 citations , March 2008 in “Journal of the American Academy of Dermatology”

research “Arrow” sign: A rapid microscopic diagnosis of hair change associated with epidermal growth factor receptor inhibitors

3 citations , August 2013 in “Journal of the American Academy of Dermatology”

A new method quickly detects hair changes from EGFR inhibitors using a microscope.

research Mitigation of epidermal growth factor receptor inhibitor-induced side effects utilizing melanin and vascular-specific lasers: A case report series

1 citations , May 2017 in “Journal of cosmetic and laser therapy”

Lasers can help reduce skin side effects from cancer treatment.

research Epidermal growth factor receptor inhibitor Geftinib-induced erosive pustular dermatosis of the scalp – A report with a brief review of the literature

November 2023 in “Journal of Skin and Sexually Transmitted Diseases”

Gefitinib can cause scalp skin issues and permanent hair loss.

research A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex

August 2024 in “Postgraduate Medical Journal”

A rare skin reaction from cancer treatment was successfully managed with topical treatments and antihistamines.

research Skin reactions caused by epidermal growth factor receptor inhibitors and their management

November 2010 in “International Journal of Dermatology and Venereology”

EGFR inhibitors can cause skin issues, and managing these is important for treatment success.

research Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System

58 citations , March 2020 in “Scientific Reports”

EGFR-TKIs can cause significant skin, nail, and organ side effects.

research Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib

57 citations , August 2006 in “Journal of the American Academy of Dermatology”

Gefitinib can cause hair loss without scarring.

research Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities

22 citations , March 2017 in “Journal of the Formosan Medical Association”

The guidelines help doctors manage skin problems from certain cancer treatments to improve patients' lives.

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

research Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor

19 citations , January 2012 in “Dermatology”

Topical human epidermal growth factor may effectively treat acne caused by cancer medication.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

research 566 Staphylococcus epidermidis for the topical treatment of epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity

July 2024 in “Journal of Investigative Dermatology”

ATR04-484 ointment shows promise for treating skin issues from cancer therapies.

Epidermal Growth Factor Receptor Mutant T790M-L858R-V948R Inhibitor from Calophyllum Inophyllum L. Leaf as Potential Non-Small Cell Lung Cancer Drugs

research Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs

April 2024 in “Journal of pharmacy & pharmacognosy research”

A compound from Calophyllum inophyllum L. leaf may help treat non-small cell lung cancer.

research Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

32 citations , April 2011 in “Journal of the American Academy of Dermatology”

Erlotinib may cause scarring hair loss.

research Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839

1 citations , March 2004 in “Journal of the American Academy of Dermatology”

ZD1839, a cancer drug, can cause mild skin rashes that are treatable without stopping the medication.

research Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor

169 citations , September 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

ZD1839 (Iressa) causes skin and hair side effects, treatable with tretinoin cream and minocycline.

research P97: Epidermal growth factor receptor inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege

July 2022 in “British Journal of Dermatology”