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GlossaryEpidermal Growth Factor Receptor

protein on cell surfaces aiding growth and division

The Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that helps them grow and divide. It is crucial in regulating cell growth, survival, and differentiation. When EGFR is mutated or overexpressed, it can lead to uncontrolled cell proliferation, which is a common feature in various cancers.

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research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor

169 citations , September 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

ZD1839 (Iressa) causes skin and hair side effects, treatable with tretinoin cream and minocycline.

Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

research Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors

138 citations , February 2007 in “European journal of cancer”

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

research Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.

107 citations , June 1997 in “PubMed”

EGFR is essential for normal hair development and follicle differentiation.

research The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome

90 citations , August 2006 in “British Journal of Dermatology”

PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

TCDD reduces EGF receptors in the liver, affecting growth and development.

research Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System

58 citations , March 2020 in “Scientific Reports”

EGFR-TKIs can cause significant skin, nail, and organ side effects.

research Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib

57 citations , August 2006 in “Journal of the American Academy of Dermatology”

Gefitinib can cause hair loss without scarring.

research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research Aberrant expression of epidermal growth factor receptor in aural cholesteatoma

48 citations , March 1993 in “The Laryngoscope”

Cholesteatoma shows abnormal and increased EGF receptor expression, indicating its rapid growth.

research Dermatological side effects of epidermal growth factor receptor inhibitors: ′Pride′ complex

43 citations , January 2014 in “Indian Journal of Dermatology”

EGFR inhibitors can cause skin issues like acne and dryness, but these can be managed without stopping treatment.

Semiology of Skin Toxicity Associated with Epidermal Growth Factor Receptor Inhibitors

research Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors

38 citations , February 2012 in “Supportive Care in Cancer”

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

research A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

33 citations , June 2009 in “Journal of Cutaneous Pathology”

Erlotinib can cause nonscarring hair loss and itchy skin.

Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition

research Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor

32 citations , June 2012 in “PLoS ONE”

Blocking IL-8 can reduce skin rashes from cancer treatment.

research Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

32 citations , April 2011 in “Journal of the American Academy of Dermatology”

Erlotinib may cause scarring hair loss.

research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

research Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities

22 citations , March 2017 in “Journal of the Formosan Medical Association”

The guidelines help doctors manage skin problems from certain cancer treatments to improve patients' lives.

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

research Role for the Epidermal Growth Factor Receptor in Chemotherapy-Induced Alopecia

20 citations , July 2013 in “PLoS ONE”

Targeting EGFR may help reduce hair loss from chemotherapy.

research Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor

19 citations , January 2012 in “Dermatology”

Topical human epidermal growth factor may effectively treat acne caused by cancer medication.

The Incidence and Management of Cutaneous Adverse Events of the Epidermal Growth Factor Receptor Inhibitors

research Histopathologic features of erythematous papulopustular eruption to epidermal growth factor receptor inhibitors in cancer patients

9 citations , October 2015 in “Journal of Cutaneous Pathology”

Erythematous papulopustular eruptions in cancer patients using EGFR inhibitors show specific skin changes that vary with severity and treatment type.

research The trichoscopic features of hair shaft anomalies induced by epidermal growth factor receptor inhibitors: A case series

7 citations , March 2020 in “Journal of the American Academy of Dermatology”

EGFR inhibitors often cause dry, brittle hair and eyebrow/eyelash changes.

research Successful treatment of epidermal growth factor receptor inhibitor–induced alopecia with doxycycline

6 citations , July 2015 in “JAAD Case Reports”

Doxycycline can effectively treat hair loss caused by EGFR inhibitors.