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GlossaryEpidermal Hyperplasia

abnormal increase in skin cell layers, causing thickened skin

Epidermal Hyperplasia, also known as epidermal thickening, is a condition where the outer layer of the skin (epidermis) undergoes an abnormal increase in the number of cells, leading to a thicker skin layer. This can be a response to chronic irritation, inflammation, or certain skin disorders, and may present as rough, scaly patches on the skin. For professionals, it is important to note that this condition can be indicative of underlying issues such as psoriasis or chronic eczema.

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research Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

100 citations , August 2008 in “American Journal Of Pathology”

VEGF-A is crucial for normal skin function and may be linked to psoriasis.

research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

Overexpressing ATF3 in mice's epithelial cells may lead to oral cancer.

research Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation

12 citations , July 2015 in “Experimental Dermatology”

Gasdermin A3 overexpression in skin causes inflammation and hair loss.

research Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

research Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia

103 citations , July 2001 in “Proceedings of the National Academy of Sciences”

TGFβ1 expression in skin causes hair loss and skin thickening, but these effects are reversible.

research Loss of epidermal PLCg1 induced sebaceous gland hyperplasia and sparse hair

April 2017 in “Journal of dermatological science”

Removing PLCg1 from skin cells caused thicker oil glands and less hair in mice.

research “Dark Cells” in Normal, Hyperplastic, and Promoter-Treated Mouse Epidermis Studied by Conventional and High-Voltage Electron Microscopy

27 citations , July 1983 in “Journal of Investigative Dermatology”

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

research Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

Overexpression of COX-2 in mice skin causes abnormal skin and hair development.

research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

147 citations , April 1997 in “Oncogene”

Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.

research Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

85 citations , March 2008 in “Journal of Cell Science”

The mutation causing Hutchinson-Gilford progeria syndrome leads to severe skin problems and early death in mice.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations , November 2017 in “Journal of developmental biology”

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

research The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles

51 citations , January 2004 in “European Journal of Cell Biology”

Human cathepsin V can replace mouse cathepsin L to maintain normal skin and hair in mice.

research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice

49 citations , August 2004 in “The FASEB Journal”

Mice with human skin protein K8 had more skin problems and cancer.

research Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter

47 citations , January 1998 in “Molecular Carcinogenesis”

ErbB2 signaling is crucial for skin cell growth and cancer development in mice.

research Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

35 citations , April 1998 in “PubMed”

Activated erbB-2 in mice skin causes severe skin and hair abnormalities.

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

research Role of bulge epidermal stem cells and TSLP signaling in psoriasis

19 citations , September 2019 in “EMBO molecular medicine”

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

research Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10.

13 citations , July 1994 in “PubMed”

Keratins K6 and K16 are expressed more freely in regenerating mouse skin than K1 and K10.

research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.

research Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis

1 citations , July 2025 in “JCI Insight”

Hair follicle stem cells help maintain skin health by moving to and supporting the skin's surface layers.

research SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation

April 2026 in “Cellular and Molecular Immunology”

SPT6 prevents excessive skin inflammation by blocking a feedback loop.

Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development

research Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

research 269 Down-regulatory role of cholecystokinin on psoriatic epidermal inflammation

April 2017 in “Journal of Investigative Dermatology”

Cholecystokinin may help reduce skin inflammation in psoriasis.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.

research Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice

11 citations , June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology

January 2005 in “Enlighten: Publications (The University of Glasgow)”

Melanocyte pathology requires keratinocyte hyperplasia and regulation dysfunction.

research Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis

59 citations , October 2017 in “Proceedings of the National Academy of Sciences”

ZIP10 is crucial for skin development and maintaining healthy skin.

research Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

195 citations , November 2001 in “The Journal of Cell Biology”

Desmocollin 1 is essential for strong skin and proper skin function.

research Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

136 citations , March 1998 in “Oncogene”

Overexpression of E2F1 can lead to skin tumors and disrupt hair growth.