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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Testosterone may slow down wound healing and increase inflammation.

Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

Microneedles offer a promising, painless way to treat skin diseases but need improvements for better use.