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GlossaryEpidermal Growth Factor

stimulates cell growth and healing in skin and hair

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth, proliferation, and differentiation by binding to its receptor, EGFR. It plays a crucial role in the healing of wounds and the regeneration of skin and hair follicles. EGF is often used in skincare products to promote skin repair and reduce signs of aging.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

Study of the Impact of SKPs' Secreted Factors and a Botanical Extract Derived from Jasmine on Keratinocyte Growth and Reconstructed Human Epidermis Thickness

research 692 Study of the impact of SKPs’ secreted factors and of a botanical extract derived from jasmine on keratinocytes growth and reconstructed human epidermis thickness

April 2016 in “Journal of Investigative Dermatology”

Jasmine extract helps skin cell growth and makes artificial skin thicker, especially when used with skin-derived precursors.

research Enriched-GF: A Reproducible High-Yield Autologous Blood-Derived Growth Factor Method for Regenerative Medicine

March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Enriched-GF method efficiently produces high-yield growth factors for tissue repair.

research Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model

8 citations , February 2025 in “Frontiers in Medicine”

IGF-1, KGF, and stem cells help skin cells move and survive, potentially speeding up wound healing.

research Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

Growth factors help hair follicle stem cells grow and stay versatile.

The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells

research The potential role of fibroblast‐derived multi‐peptide factors in activation of growth factors and β‐Catenin in hair follicle cells

4 citations , June 2022 in “Journal of Cosmetic Dermatology”

Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome

6 citations , December 2023 in “Journal of Clinical Medicine”

Abnormal growth factor metabolism may link psoriasis and metabolic syndrome, and obesity can affect psoriasis treatment effectiveness.

research Subcutaneous injection of conditioned medium from photobiomodulation-treated adipose-derived stromal cells promotes hair growth and angiogenesis in mice

June 2025 in “Archives of Dermatological Research”

Light-treated cell medium boosts hair growth in mice.

research Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration

25 citations , February 2024 in “Biomaterials”

Stem cell-derived organoids can improve skin healing.

research 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons

November 2024 in “Journal of Investigative Dermatology”

Red ginseng components help prevent skin aging by reducing inflammation and improving cell function.

research Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

83 citations , May 2013 in “International Journal of Molecular Sciences”

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

research A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin

14 citations , January 2020 in “Research Journal of Pharmacy and Technology”

Fat and hair follicle stem cells can become neurons, useful for treating brain diseases.

research Isolation and Cultivation of Skin-Derived Precursors

3 citations , January 2018 in “Methods in molecular biology”

The document concludes that skin-derived precursors can be grown and may help in hair growth and skin repair.

research In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs

3 citations , December 2007 in “Journal of Otology”

Guinea pig fat stem cells can become hair cell-like cells in a lab.

research Different levels of EGF, VEGF, IL‐6, MCP‐1, MCP‐3, IP‐10, Eotaxin and MIP‐1α in the adipose‐derived stem cell secretome in androgenetic alopecia

1 citations , February 2022 in “Experimental Dermatology”

Certain proteins are found at higher levels in balding areas compared to non-balding areas, suggesting a link to hair loss. This could be useful for diagnosing and treating hair loss.

research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

19 citations , January 2017 in “Stem Cells International”

Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.

research Hair follicle bulge-derived stem cells promote tissue regeneration during skin expansion

27 citations , October 2020 in “Biomedicine & Pharmacotherapy”

Hair follicle stem cells help skin heal and grow better.

research HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation

20 citations , December 2019 in “International Journal of Molecular Sciences”

HB-EGF boosts the hair growth ability of stem cells, making it a potential hair loss treatment.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations , June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

research Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss

3 citations , August 2022 in “Molecules/Molecules online/Molecules annual”

A new strain of bacteria from the human skin can help prevent hair loss.

Effect of Conditioned Media Collected from Human Amniotic Fluid-Derived Stem Cells on Skin Regeneration and Photo-Aging

research Effect of conditioned media collected from human amniotic fluid-derived stem cells (hAFSCs) on skin regeneration and photo-aging

9 citations , February 2014 in “Tissue Engineering and Regenerative Medicine”

Conditioned media from human amniotic fluid-derived stem cells helps skin heal and protects against aging from sun exposure.

research Recurrent inverse necrotizing infundibular crystalline folliculitis

1 citations , April 2024 in “Journal of Cutaneous Pathology”

Recurrent NICF is a rare skin condition with unclear causes, involving follicle inflammation and crystal deposits.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells

5 citations , January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research Stem Cells in Dermal Wound Healing

5 citations , January 2004

Stem cells help heal skin wounds by supporting tissue repair and regeneration.

research MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction

February 2026 in “Biomedicine & Pharmacotherapy”

MLPH helps hair grow by activating IGF-1 signaling in hair cells.