Growth Factors IGF-1 and KGF and Adipose-Derived Stem Cells Promote Migration and Viability of Primary Human Keratinocytes in an In Vitro Wound Model

The study investigates the effects of growth factors IGF-1 and KGF, along with adipose-derived stem cell-conditioned medium (ADSC-CM), on the migration and viability of primary human keratinocytes in an in vitro wound model. Results showed that both growth factors and ADSC-CM enhanced keratinocyte migration and viability, with the potential for clinical application in improving epidermal transplantation for chronic wound treatment. The study also successfully isolated keratinocytes in a xenogen-free medium, crucial for clinical use. However, the effects varied depending on the patient, indicating a need for personalized approaches. These findings suggest that incorporating these factors could accelerate wound healing and reduce recovery time for patients.