April 2024 in “Asian Journal of Medical Sciences” Ring block anesthesia is best for comfort and acceptance in PRP hair loss treatments.
3 citations
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November 2022 in “Facial plastic surgery & aesthetic medicine” Using ultrasound to guide temple filler injections improves safety and accuracy.
July 2026 in “Current Medical Issues” Topical anesthetics don't effectively reduce pain during scalp PRP injections.
January 2024 in “Journal of Cutaneous and Aesthetic Surgery” The modified needle is safer for procedures by reducing injury risk.
3 citations
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May 2016 in “Journal of Cutaneous Medicine and Surgery” The document suggests using small syringes, distraction techniques, topical anesthetics, and specific drugs to ensure a pain-free experience during hair restoration surgery.
June 2022 in “Zenodo (CERN European Organization for Nuclear Research)” Microneedles offer a painless way to deliver drugs effectively but need more research before they can be widely used.
January 2022 in “Journal of Cutaneous and Aesthetic Surgery” Using truncal anesthesia on the supraorbital nerve reduces pain in hair loss treatments and improves patient comfort.
March 2025 in “Pain Physician” Cooling the skin before injections reduces pain for patients with hair loss.
January 2019 in “Headache” Peripheral nerve blocks are a safe and effective way to treat various headaches and provide lasting pain relief.
February 2024 in “Curēus” Regional nerve blocks are better than ring blocks for pain relief during PRP hair treatment.
13 citations
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April 2001 in “Journal of The American Academy of Dermatology” Using a vibrating device during injections can help reduce pain.
April 2016 in “Journal of Investigative Dermatology” Microneedle arrays deliver botulinum toxin effectively for sweat suppression, similar to injections.
December 2024 in “African Journal of Biomedical Research” Combining dexmedetomidine and ketamine provides better sedation and pain relief than dexmedetomidine alone.
26 citations
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July 2023 in “International Journal of Nanomedicine” The microneedle system shows promise for non-invasive brain drug delivery.
Microneedles could revolutionize pediatric medicine by offering painless drug delivery, but more development is needed.
September 2024 in “Journal of Cosmetic Dermatology” Cold gel compresses are the best for pain relief during scalp microneedling.
1 citations
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January 2022 in “Pharmaceutical Sciences Asia” Microneedles offer a painless, effective way to deliver drugs through the skin.
1 citations
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February 2021 Ice packs and vibration devices can reduce pain during scalp injections.
3 citations
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February 2002 in “Dermatologic Surgery” Using a handheld massage device during hair transplant significantly reduces pain for most patients.
4 citations
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July 2016 in “Dermatologic Surgery” Higher epinephrine concentration and specific injection sites increase scalp vasoconstriction time.
4 citations
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March 2002 in “Hair transplant forum international” Using tumescent anesthesia in hair restoration surgery is safe and effective for long-lasting scalp numbness and reducing bleeding.
1 citations
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May 2022 in “Голова и шея.” The anesthesia protocol with fentanyl and propofol caused the least pain during septoplasty.
Follicular unit extraction is safe and effective without bupivacaine and nerve blocks when using lignocaine with adrenaline.
October 2023 in “Facial Plastic Surgery” Local anesthesia with a "ring block" is preferred for pain control during FUE hair transplant procedures.
May 2018 in “Dermatologic Surgery”
July 2003 in “Hair transplant forum international” PEMA handles on syringes improve comfort and efficiency in hair transplant procedures.
12 citations
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April 2025 in “Discover Pharmaceutical Sciences” Microneedle patches offer painless, effective drug delivery and are suitable for all ages.
May 2026 in “International Journal of Drug Delivery Technology” Adrenaline infiltration improves hair transplant efficiency and safety.
140 citations
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December 2017 in “Journal of Controlled Release” Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.
2 citations
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March 2024 in “Pharmaceutics” The placebo microneedle stamp didn't penetrate skin and caused less pain, but blinding was only effective for those with low skin sensitivity.