November 2025 in “Frontiers in Endocrinology” Apigenin and ellagic acid may help manage PCOS symptoms.
508 citations
,
February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
305 citations
,
February 2007 in “Hormone and metabolic research” Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
260 citations
,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
142 citations
,
January 2019 in “Frontiers in Neuroendocrinology” Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.
96 citations
,
October 1981 in “Drugs” Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.
87 citations
,
July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
87 citations
,
July 2018 in “Nursing Clinics of North America” PCOS is a common hormonal disorder in women, marked by symptoms like hair growth and menstrual issues, and requires personalized treatment.
86 citations
,
June 2017 in “Anais Brasileiros de Dermatologia” Antioxidants can benefit skin health but should be used carefully to avoid negative effects.
82 citations
,
March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
81 citations
,
May 2007 in “Fertility and Sterility” Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.
75 citations
,
October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
63 citations
,
May 2011 in “Clinical cancer research” The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
57 citations
,
December 2018 in “JAMA Surgery” Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.
55 citations
,
January 2007 in “Climacteric” Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.
40 citations
,
December 2019 in “Neurobiology of Stress” Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.
32 citations
,
December 2018 in “Cytokine” Type I interferons play a key role in the development of various skin diseases.
32 citations
,
December 2014 in “Cold Spring Harbor Perspectives in Medicine” Disruptions in epidermal polarity genes can lead to skin diseases.
30 citations
,
February 2003 in “Annals of Neurology” Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.
29 citations
,
June 2004 in “Pharmacology, Biochemistry and Behavior” Finasteride reduces alcohol withdrawal effects, especially in female mice.
26 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.
25 citations
,
January 2015 in “Advances in Psychosomatic Medicine” Many skin patients also have mental health issues, and doctors should treat both together.
24 citations
,
July 2017 in “Structure” FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.
23 citations
,
February 2020 in “PLOS genetics” Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.
17 citations
,
April 2007 in “Kidney international” Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.
15 citations
,
June 2018 in “Food Reviews International” Pumpkin seed oil may improve prostate health, bladder control, and hair growth in men.
14 citations
,
October 2018 in “Brain Research Bulletin” Exosomes help nerve fibers grow by affecting specific cell signaling pathways.
13 citations
,
December 2017 in “BMC Complementary and Alternative Medicine” The Asian herbal mix with Houttuynia cordata, Perilla frutescens, and green tea helped grow hair in mice.
12 citations
,
January 2016 in “Journal of Assisted Reproduction and Genetics” Certain gene variations are linked to higher male hormone levels in Chinese women with PCOS and insulin resistance.
9 citations
,
August 2024 in “Tissue Engineering and Regenerative Medicine” Collagen-heparin-FGF2-VEGF scaffolds can improve skin healing.