Exploring the Therapeutic Potential of Phytochemicals Apigenin and Ellagic Acid in Managing Polycystic Ovarian Syndrome and Its Comorbidities: A Comprehensive Review

    November 2025 in “ Frontiers in Endocrinology ”
    Acharya Balkrishna, Maneesha Rana, Shalini Mishra, Ritik Agrawal, Satyendra Kumar Rajput, Muralikrishnan Dhanasekaran, M. K. Rana, Vedpriya Arya, Ramith Ramu, Ashutosh Upadhayay, Shalini Singh
    TLDR Apigenin and ellagic acid may help manage PCOS symptoms.
    This review explores the potential of apigenin and ellagic acid, two phytochemicals, in managing Polycystic Ovarian Syndrome (PCOS) and its comorbidities. Both compounds exhibit anti-inflammatory, antioxidant, insulin-sensitizing, and anti-androgenic properties, which may help regulate ovarian steroidogenesis, improve insulin sensitivity, and reduce hyperandrogenism. Preclinical and preliminary clinical studies suggest these bioactives can restore ovarian morphology and normalize hormonal profiles in PCOS models. Despite challenges with bioavailability, innovative delivery systems like nano-delivery and liposomes could enhance their clinical use. The review calls for well-designed clinical trials to confirm efficacy and establish dosing guidelines.
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      community Procapil - Has anyone heard of it?!

      in Research/Science  1 upvotes 3 years ago
      The conversation discusses Procapil, a treatment for hair loss containing Apigenin and Oleanolic acid. Users are sharing their experiences and asking if anyone has tried it.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Natural Remedies: Polyphenols and Hair Loss

       18 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Redensyl Megathread !!!!

       43 upvotes 6 years ago
      Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

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      in Finasteride  6 upvotes 6 years ago
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