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GlossaryEstrogen Receptor-Positive Breast Cancer

cancer type where cells grow due to estrogen binding

Estrogen Receptor-Positive Breast Cancer (ER+ Breast Cancer) is a type of breast cancer where the cancer cells have receptors that bind to the hormone estrogen. This binding promotes the growth of the cancer cells. Treatments often involve hormone therapies that block estrogen from attaching to these receptors, thereby slowing or stopping the cancer's growth.

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research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis

18 citations , August 2019 in “Clinical breast cancer”

Local hormonal treatment for vulvovaginal atrophy is likely safe for women with estrogen receptor-positive breast cancer on aromatase inhibitors.

research Patient-Reported Outcomes From Phase III Neoadjuvant Systemic Trial Comparing Neoadjuvant Chemotherapy With Neoadjuvant Endocrine Therapy in Pre-Menopausal Patients With Estrogen Receptor-Positive and HER2-Negative, Lymph Node-Positive Breast Cancer

1 citations , July 2021 in “Frontiers in Oncology”

Neoadjuvant endocrine therapy led to a better future outlook than chemotherapy, with no major quality of life differences.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

research Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome

7 citations , September 2023 in “Cancer Treatment Reviews”

Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.

Clinical Aspects, Pathogenesis, and Therapy Options of Alopecia Induced by Hormonal Therapy for Breast Cancer

research Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

2 citations , October 2021 in “Exploration of targeted anti-tumor therapy”

Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.

research Aldosterone- and cortisol-cosecreting adrenal adenoma, ovarian hyperthecosis and breast cancer

1 citations , September 2020 in “Endocrinology, Diabetes & Metabolism Case Reports”

The conclusion is that thorough investigation of hypertension and hormonal dysfunctions is important, and there may be a link between these conditions and cancer.

research 202 Activation of breast cancer cell proliferation by ROR-alpha through aromatase promoter

March 2010 in “Ejc Supplements”

ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.

research Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents

67 citations , October 2005 in “Annals of Oncology”

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

research Ductal breast cancer in a male patient

October 2010 in “International Journal of Dermatology”

An 86-year-old man with prostate cancer was diagnosed with a rare, low-grade breast cancer and underwent surgery but declined additional hormone therapy.

research Cancer risk in polycystic ovary syndrome patients: Common treatments and future perspectives

June 2023 in “Journal of multidisciplinary sciences (Online)”

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations , March 2005 in “Endocrine Reviews”

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

research Drug safety evaluation of exemestane

7 citations , March 2011 in “Expert Opinion on Drug Safety”

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

research Androgen receptor: A promising therapeutic target in breast cancer

21 citations , March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

research Aromatase inhibitors induce ‘male pattern hair loss’ in women?

19 citations , May 2013 in “Annals of Oncology”

Aromatase inhibitors cause male pattern hair loss in women.

research Estrogens and aging skin

150 citations , April 2013 in “Dermato-endocrinology”

Estrogen therapy can reduce skin aging but has cancer risks.

Interaction Between Estrogens and Androgen Receptor Genes Microsatellites, Prostate-Specific Antigen, and Androgen Receptor Expressions in Breast Cancer

research Interaction between estrogens and androgen receptor genes microsatellites, prostate-specific antigen and androgen receptor expressions in breast cancer

6 citations , January 2010 in “Neoplasma”

Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

CDK4/6 inhibitors have improved treatment outcomes for certain advanced breast cancer patients.

research Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer

2 citations , December 2013 in “Cancer research”

Enobosarm may effectively treat androgen receptor-positive breast cancer with fewer side effects.

research Revising the role of the androgen receptor in breast cancer

68 citations , April 2014 in “Journal of Molecular Endocrinology”

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

research Hair regrowth in endocrine therapy alopecia with dutasteride treatment in woman with estrogen positive breast cancer

March 2023 in “JAAD case reports”

Outcome and Clinical-Biological Characteristics of Patients with Advanced Breast Cancer Undergoing Removal of Ovarian/Pelvic Metastases

research Outcome and clinical–biological characteristics of patients with advanced breast cancer undergoing removal of ovarian/pelvic metastases

2 citations , May 2012 in “Annals of Oncology”

Patients with advanced breast cancer and high hormone receptor levels who had surgery for ovarian/pelvic metastases lived longer, especially if they had high estrogen receptor levels.

research The evolution of primary multimodality treatment in resectable breast cancer

13 citations , August 1980 in “Cancer”

Multimodal primary treatment improves survival in premenopausal breast cancer patients and is also beneficial for postmenopausal women.

Nutraceuticals Known to Promote Hair Growth Do Not Interfere With the Inhibitory Action of Tamoxifen in MCF7, T47D and BT483 Breast Cancer Cell Lines

research Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in MCF7, T47D and BT483 breast cancer cell lines

February 2024 in “PloS one”

Nutraceuticals that promote hair growth do not reduce tamoxifen's effectiveness in breast cancer treatment.

research Female pattern hair loss possibly caused by tamoxifen: Androgen receptor expression in the outer root sheath in the affected area

5 citations , August 2012 in “Journal of Dermatology”

Tamoxifen may cause female hair loss by increasing androgen receptor expression.

research Canadian Expert Recommendations on Safety Overview and Toxicity Management Strategies for Sacituzumab Govitecan Based on Use in Metastatic Triple-Negative Breast Cancer

6 citations , September 2024 in “Current Oncology”

Sacituzumab Govitecan is effective for certain breast cancers but requires careful management of side effects.

research Nutraceuticals Known To Promote Hair Growth Do Not Interfere With The Inhibitory Action of Tamoxifen In MCF7, T47D And BT483 Breast Cancer Cell Lines

February 2022 in “Research Square (Research Square)”

Certain nutraceuticals may enhance hair growth without affecting the cancer-fighting properties of tamoxifen.

research 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma

March 2010 in “Ejc Supplements”

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

research Effect of estrogens on skin aging and the potential role of SERMs

120 citations , October 2007 in “Clinical Interventions in Aging”

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

research A systematic review of health-related quality of life outcomes in patients with advanced breast cancer treated with palbociclib

7 citations , September 2024 in “Journal of Comparative Effectiveness Research”

Palbociclib generally maintains or improves quality of life in advanced breast cancer patients.

Optimizing Clinical Monitoring and Management Guidelines for Capivasertib in HR-Positive/HER2-Negative Advanced Breast Cancer: Expert Opinion

research Optimizing clinical monitoring and management guidelines for capivasertib in HR-positive/HER2-negative advanced breast cancer: expert opinion

December 2025 in “npj Breast Cancer”

Capivasertib improves survival in certain breast cancer cases but requires careful management of side effects.