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GlossaryEstrogenic Activity

ability of a substance to mimic or influence estrogen effects

Estrogenic activity refers to the ability of a substance to mimic or influence the effects of estrogen, a primary female sex hormone, in the body. This can impact various biological processes, including reproductive health, bone density, and hair growth. Substances with estrogenic activity can bind to estrogen receptors and trigger similar responses as natural estrogen, which is why they are significant in both medical treatments and environmental health studies.

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Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

research Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

July 2025 in “Reproductive Biology and Endocrinology”

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

research PSAT217 Estrogen Deficiency as a Cause of Decreased 1- alpha - hydroxylase Activity

November 2022 in “Journal of the Endocrine Society”

Estrogen deficiency can reduce the enzyme activity needed to activate vitamin D.

research Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

11 citations , November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Hormonal Activity in Commonly Used Black Hair Care Products: Evaluating Hormone Disruption as a Plausible Contribution to Health Disparities

research Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities

25 citations , May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology”

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

research Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha

April 2026 in “microPublication”

Minoxidil might partially activate estrogen receptors, affecting hair growth.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

research 17α‐estradiol induces aromatase activity in intact human anagen hair follicles ex vivo

94 citations , August 2002 in “Experimental Dermatology”

17α-estradiol boosts aromatase activity in female hair follicles, potentially helping with hair loss.

Estrogens and Human Scalp Hair Growth: More Questions Than Answers

research Estrogens and Human Scalp Hair Growth—Still More Questions than Answers

44 citations , March 2004 in “Journal of Investigative Dermatology”

The effects of estrogen on human hair growth are unclear and need more research.

research The effect of treatment with an LH-RH agonist (Buserelin) on gonadal activity growth and bone maturation in children with central precocious puberty

34 citations , May 1987 in “European Journal of Pediatrics”

Buserelin safely and effectively suppresses early puberty, potentially improving final height.

research Antiandrogenic activities ofGlycyrrhiza glabrain male rats

15 citations , January 2009 in “International Journal of Andrology”

Liquorice may reduce testosterone and affect male reproductive organs, potentially helping treat conditions like prostate cancer.

research Adrenal and Gonadal Activity, Androgen Concentrations, and Adult Height Outcomes in Boys With Silver-Russell Syndrome

1 citations , December 2019 in “Frontiers in endocrinology”

Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.

The Expressions of Androgen Receptors and Estrogen Receptors in Bald and Non-Bald Areas of Androgenic Alopecia

research The Expressions of Androgen Receptors and Estrogen Receptors in Bald and Non-bald Area of Androgenic Alopecia

1 citations , January 2002 in “Journal of Clinical Dermatology”

Hair loss in androgenic alopecia may be linked to increased local androgen activities, but not to estrogen levels.

Floral Attractants in the Black Orchid Brasiliorchis Schunkeana: Clues for Presumed Sapromyophily and Potential Antimicrobial Activity

research Floral attractants in the black orchid Brasiliorchis schunkeana (Orchidaceae, Maxillariinae): clues for presumed sapromyophily and potential antimicrobial activity

1 citations , December 2022 in “BMC Plant Biology”

The black orchid Brasiliorchis schunkeana produces chemicals that attract certain insects and have potential antimicrobial properties.

research Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

9 citations , April 2019 in “Molecules”

Blackcurrant extract may help reduce hair loss by promoting stem cell activity in hair follicles.

research The Effects of Perinatal Androgen Deprivation on Locomotor Activity in Male Rats

1 citations , April 2015 in “The FASEB Journal”

Blocking androgens in male rats increased estrogen and made them more active.

Multiple Readout Assay for Hormonal (Androgenic and Antiandrogenic) and Cytotoxic Activity of Plant and Fungal Extracts Based on Differential Prostate Cancer Cell Line Behavior

research Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior

19 citations , August 2014 in “Journal of Ethnopharmacology”

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

research A Case of Virilizing Brenner Tumor in a Postmenopausal Woman With Stromal Androgenic Activity

6 citations , June 2006 in “International Journal of Gynecological Pathology”

A postmenopausal woman's hormone imbalance and symptoms improved after removing benign ovarian tumors.

research Final Report on the Safety Assessment of Human Placental Protein, Hydrolyzed Human Placental Protein, Human Placental Enzymes, Human Placental Lipids, Human Umbilical Extract, Placental Protein, Hydrolyzed Placental Protein, Placental Enzymes, Placental Lipids, and Umbilical Extract

13 citations , April 2002 in “International Journal of Toxicology”

The safety of placental and umbilical extracts in cosmetics is uncertain, requiring more research.

research Selective androgen receptor modulators: a critical appraisal

2 citations , September 2025 in “Frontiers in Endocrinology”

SARMs show promise but need more evidence to prove they're better than traditional androgens.

Clinical Aspects, Pathogenesis, and Therapy Options of Alopecia Induced by Hormonal Therapy for Breast Cancer

research Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

2 citations , October 2021 in “Exploration of targeted anti-tumor therapy”

Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.