Final Report on the Safety Assessment of Human and Animal Placental and Umbilical Extracts in Cosmetics
April 2002
in “
International Journal of Toxicology
”
human placental protein hydrolyzed human placental protein human placental enzymes human placental lipids human umbilical extract placental protein hydrolyzed placental protein placental enzymes placental lipids umbilical extract estrogenic activity biological activity skin sensitization toxicity photosensitization genotoxicity ocular toxicity metabolic activity endocrine activity
TLDR The safety of placental and umbilical extracts in cosmetics is uncertain, requiring more research.
The report assessed the safety of various human and animal placental and umbilical extracts used in cosmetics. It highlighted that human-derived ingredients, such as Human Placental Protein, were prohibited in the EU due to concerns about disease transmission, while animal-derived ingredients were still in use. The report noted that most available data related to placental derivatives with potential estrogenic or biological activity, but there was insufficient data to confirm their safety in cosmetics. It recommended further studies on skin sensitization, toxicity, genotoxicity, and other safety aspects. The report concluded that cosmetic ingredients should not deliver any metabolic or endocrine activity and should be free of detectable pathogens.
