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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

research Assessment of the Pharmacokinetic -Pharmacodynamic Interaction Between Terazosin and Finasteride

6 citations , December 1996 in “The Journal of Clinical Pharmacology”

Terazosin and finasteride together cause no major issues.

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

research Study on Human Bioequivalency of Two Preparations of Finasteride

January 2005 in “Journal of Elinical Research”

The two finasteride preparations are bioequivalent.

Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes

research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

research Metabolic pathway of Cis-UCA upon Ultraviolet B (UVB) exposure using ¹H Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Docking and cell viability of human keratinocytes (HaCaT) cell lines

February 2026 in “UiTM Institutional Repositories (Universiti Teknologi MARA)”

Cis-UCA can form new compounds without enzymes, and sulphide donors reduce its UVB-induced toxicity in skin cells.

research Heterozygous COL5A1 deletion in a cat with classical Ehlers–Danlos syndrome

May 2024 in “Animal genetics”

A cat's poor wound healing was linked to a genetic deletion in the COL5A1 gene.

research 5α‐Reductase Isozymes and Androgen Actions in the Prostate

93 citations , February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

research Preformulation studies of finasteride to design matrix systems for topical delivery

14 citations , August 2018 in “Journal of Pharmaceutical and Biomedical Analysis”

research Finasteride Induced Clinical Ocular Toxicity

January 2018 in “Investigative Ophthalmology & Visual Science”

research Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones

75 citations , August 2006 in “International Journal of Pharmaceutics”

The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.

research Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2

1 citations , January 2021 in “Research Square (Research Square)”

Enzalutamide, a prostate cancer drug, may help prevent COVID-19 by blocking the virus from entering lung cells.

research A finasteride patch for the treatment of androgenetic alopecia: A study of promoting permeability strategy using synthetic novel O-acylmenthols combined with ion-pair

October 2024 in “International Journal of Pharmaceutics”

The finasteride patch effectively treats hair loss by enhancing skin absorption.

Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

14 citations , January 2020 in “International Journal of Biological Sciences”

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

research Comprehensive Evaluationof Tectonagrandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-ReductaseInhibition and Anti-Inflammatory Properties

November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Tectona grandis leaves may help treat hair loss and inflammation.

research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

Osmanthus fragrans var. aurantiacus Makino may help treat inflammation due to its antioxidative and anti-inflammatory properties.

research Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide

130 citations , January 2000 in “Nature biotechnology”

Methylation of CpG Islands in Promoter of Type 2 5-Alpha Reductase and Implications of Finasteride Resistance for BPH Therapy

research 102 Methylation of CpG islands in promoter of type 2 5-α reductase and implications of finasteride resistance for BPH therapy

March 2016 in “European Urology Supplements”

Methylation in specific gene region causes finasteride resistance in some BPH patients.

research LAM/TSC Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis. Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin

2 citations , January 2014 in “Journal of Cytology & Histology”

Rapamycin and anti-EGFR antibody reduce LAM/TSC cell migration and blood vessel growth in the uterus.

25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Pre-keratin isolated from epidermal microsomes

7 citations , December 1970 in “Biochimica et Biophysica Acta (BBA) - Protein Structure”

research Enhancement of Dermal Delivery of Finasteride Using MicroemulsionSystems

18 citations , October 2019 in “Advanced Pharmaceutical Bulletin”

Microemulsions can improve skin delivery of finasteride.

research Matriptase: Potent Proteolysis on the Cell Surface

165 citations , January 2006 in “Molecular Medicine”

Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.

research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function

October 2023 in “Journal of pharmaceutical investigation”

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

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