Search

for
Search:

Did you mean Extracellular Matrix Organization?

GlossaryExtracellular Matrix Organization

network of proteins and molecules outside cells is structured

Extracellular Matrix Organization (ECM Organization) refers to the process by which the network of proteins and other molecules outside cells is structured and maintained. This matrix provides structural support to tissues, influences cell behavior, and plays a crucial role in wound healing, tissue repair, and overall cellular function. Proper ECM organization is essential for maintaining healthy skin and hair, and disruptions in this process can contribute to conditions like alopecia.

Related Terms

Sort by

Research

30 / 1000+ results

Intraoperative Bioprinting of Human Adipose-Derived Stem Cells and Extracellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation During Full-Thickness Craniomaxillofacial Skin Reconstruction

research Intraoperative Bioprinting of Human Adipose-derived Stem cells and Extra-cellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation during Full-thickness Craniomaxillofacial Skin Reconstruction

1 citations , October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Printing human stem cells and a special matrix during surgery can help grow new skin and hair-like structures in rats.

research Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation

20 citations , September 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

MMP-9 is essential for proper hair canal formation.

Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device

research Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device

March 2024 in “Advanced healthcare materials/Advanced Healthcare Materials”

Scientists developed a new way to create skin-like structures from stem cells using a special 3D gel and a device that improves cell organization and increases hair growth.

Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages

research Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages

March 2024 in “Advanced science”

A new hydrogel made from human cells improves wound healing by working with immune cells to promote repair.

research [Retracted] Fibroblasts in Scar Formation: Biology and Clinical Translation

18 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.

research Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype

35 citations , October 2017 in “Signal Transduction and Targeted Therapy”

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.

research Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds

150 citations , June 2014 in “Biomaterials”

Peptide hydrogels heal burn wounds faster and better than standard dressings.

research Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

66 citations , May 2021 in “Science Advances”

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

research LB881 Unraveling mechanisms of scarring alopecia in discoid lupus: Insights from spatial transcriptomics

July 2024 in “Journal of Investigative Dermatology”

CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss in Discoid Lupus.

research Distinct fibroblast lineages determine dermal architecture in skin development and repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing

263 citations , February 2020 in “International journal of molecular sciences”

ADSCs help in wound healing and skin regeneration but need more research for full understanding.

research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

238 citations , March 2013 in “Development”

Fat cells help recruit healing cells and build skin structure during wound healing.

research A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration

19 citations , April 2021 in “Stem Cell Research & Therapy”

SVF cell transplantation improves skin regeneration safely.

research Skinny Fat Cells Stimulate Wound Healing

9 citations , June 2020 in “Cell stem cell”

Skinny fat cells help wounds heal faster by releasing fatty acids.

research The Therapeutic Role of ADSC-EVs in Skin Regeneration

7 citations , June 2022 in “Frontiers in Medicine”

ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.

research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

2 citations , September 2023 in “International journal of molecular sciences”

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

research Hair Regeneration under Stress

2 citations , May 2018 in “Journal of Investigative Dermatology”

Mice can regrow hair on wounds due to specific cell interactions and mechanical forces not seen in rats.

research An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice ( Acomys )

1 citations , April 2023 in “Science Advances”

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

research Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies

September 2025 in “Frontiers in Cell and Developmental Biology”

Retinoic acid may help heal skin without scars by reducing fibrosis and supporting skin regeneration.

research 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa

November 2024 in “Journal of Investigative Dermatology”

Scalp hair follicle cells help protect and heal skin in certain skin conditions.

research 613 Bacteria induce skin regeneration via IL-1β signaling

April 2021 in “Journal of Investigative Dermatology”

Bacteria can help skin regenerate through a process called IL-1β signaling.

research Biomimetic and Estrogenic Plant-Based Nanofibrous Wound Dressings

March 2019 in “Digital Access to Scholarship at Harvard (DASH) (Harvard University)”

Soy-based wound dressings can speed up healing and tissue regeneration.

research Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin

14 citations , July 2019 in “Journal of Investigative Dermatology”

Integrin-linked kinase is crucial for melanoblasts to properly colonize the skin.

research Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

5 citations , February 2024 in “Frontiers in bioengineering and biotechnology”

Electrospun scaffolds can improve healing in diabetic wounds.

Differential Expression of Fibromodulin, a Transforming Growth Factor-Beta Modulator, in Fetal Skin Development and Scarless Repair

research Differential Expression of Fibromodulin, a Transforming Growth Factor-β Modulator, in Fetal Skin Development and Scarless Repair

168 citations , August 2000 in “American Journal of Pathology”

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.