A Randomized, Controlled Clinical Trial of Autologous Stromal Vascular Fraction Cells Transplantation to Promote Mechanical Stretch-Induced Skin Regeneration

This study investigated the effects of autologous stromal vascular fraction (SVF) cells combined with mechanical stretching on skin regeneration in a randomized, controlled clinical trial with 20 participants. The SVF group showed significantly greater skin thickness and improved texture at 8 and 12 weeks compared to the control group. Histological analysis revealed increased cell proliferation, blood vessel formation, and extracellular matrix volume in SVF-treated skin. No severe adverse events were reported, indicating the treatment's safety. The findings suggested that SVF cell transplantation could enhance mechanical stretch-induced skin regeneration and aid in clinical reconstruction, although further research with larger sample sizes and longer follow-up was needed.