19 citations
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January 2012 in “Frontiers in Neural Circuits” Neurosteroids and benzodiazepines reduce neuron excitability, with lasting effects on inhibitory neurons.
4 citations
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April 2017 in “F1000Research” Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
November 2003 in “Journal of Neurochemistry” Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.
11 citations
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July 2015 in “Journal of Anatomy” SLVs help maintain muscle stretch sensitivity and could aid in treating hypertension and muscle spasticity.
238 citations
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February 2007 in “Journal of Neuroscience” Ovarian and stress hormones can change GABA A receptors through neurosteroids.
16 citations
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November 2018 in “Medicinal Chemistry” The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.
60 citations
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May 2006 in “Journal of Neurochemistry” Social isolation makes rats more sensitive to alcohol's effects on the brain.
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August 2014 in “PLoS ONE” GFRα2 is essential for controlling neuron size but not for target innervation in certain sensory neurons.
August 2008 in “European Neuropsychopharmacology” RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.
40 citations
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December 2019 in “Neurobiology of Stress” Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.
248 citations
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December 2011 in “Journal of Neuroscience” Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.
August 2021 in “The Journal of Physiology” NKCC1 transporters help control neuron excitability and inhibition.
12 citations
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December 2009 in “Neuroscience” GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” Dopamine receptors in the brain influence itch-related scratching behavior.
1 citations
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April 2011 in “The FASEB Journal” Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.
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November 2018 in “The journal of pain/Journal of pain” 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.
April 2008 in “Annals of General Psychiatry” Social isolation changes brain receptors and makes ethanol more impactful.
48 citations
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September 2007 in “European Journal of Neuroscience” Ethanol blocks memory formation in rats by enhancing certain brain chemicals.
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February 2012 in “Clinical Neurology and Neurosurgery” Dystonia may be part of PAS-4 and linked to immune issues.
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February 2019 in “Neuroscience letters” Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.
12 citations
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June 2019 in “Psychoneuroendocrinology” Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
6 citations
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July 2016 in “Doklady Biochemistry and Biophysics” GD-23 reduces anxiety by relying on neurosteroid production.
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June 2011 in “Movement Disorders” A specific gene mutation is linked to a hereditary form of dystonia that responds well to certain medications.
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January 2008 in “Pharmacology Biochemistry and Behavior” AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.
December 2025 in “Molecular Pain” Targeting the MC-5-HT-HTR2A axis may help treat chronic itching.
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May 2019 in “Scientific Reports” Late pregnancy helps repair brain damage in rats due to the GABAergic system.
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November 2013 in “PLoS ONE” Estrogen and androgen signals control synaptic changes in rat brains.
Meis2 is essential for touch sensation and nerve function in mice.
April 2019 in “Journal of Investigative Dermatology” Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.
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May 2003 in “PubMed” Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.