research 487 Exploring ribosomal RNA modifications and corresponding snoRNAs in human skin cell senescence
Understanding snoRNA regulation may help slow skin aging.
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390-420 / 1000+ resultsresearch Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism
Red light exposure can slow aging in mice by improving fat metabolism.
research 575 Senescent atrophic epidermis retains Lrig1+ stem cells and loses Wnt signaling, a phenotype shared with CD44KO mice
research Intracellular protons accelerate aging and switch on aging hallmarks in mice
Acid inside cells speeds up aging and turns on aging signs in mice.
research 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets
The research found that blocking a gene called NEMO can potentially prevent harmful effects of aging at the cellular level.
research Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy
Older skin has higher cancer risk due to inflammation and stem cell issues.
research Exploring Human Skin Aging at the Single-Cell Level
Middle-aged skin shows aging signs, and quercetin might help delay them.
research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging
Epigenetic and metabolic changes affect stem cell function and aging in skin.
research Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration
Senescence and genomic instability in fibroblasts contribute to hair loss and impaired skin regeneration with age.
research Premature aging syndromes: From patients to mechanism
Studying premature aging syndromes helps understand human aging and suggests potential treatments.
research Causality of Aging Hallmarks
Lengthening telomeres may reverse aging and extend lifespan.
research 1349 Inducing fate changes at the hair follicle stem cell nice
The study found that aging hair follicle stem cells change behavior, leading to hair loss, but drugs targeting these cells may help restore hair growth.
research 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes
Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.
research 866 Senescent fibroblasts secretome promote tumoural initiation of normal human keratinocytes through cellular activation, enhanced migration and ECM remodelling
Senescent fibroblasts can help start tumors in normal skin cells.
research Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
Aging changes sugar molecules on skin stem cells, which may affect their ability to repair skin.
research Replicative stress, stem cells and aging
Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.
research Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors
Genetics, epigenetics, and lifestyle all influence facial skin aging.
research Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction
Stress can cause early aging in certain skin cells, leading to problems with hair growth.
research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss is caused by the breakdown of a protein called COL17A1 in hair follicle stem cells.
research Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway
The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.
research 1344 Novel human 3D skin model for skin aging research
Scientists created a 3D skin model that shows typical signs of aging, which can help in aging research.
research Montagna Symposium 2014—Skin Aging: Molecular Mechanisms and Tissue Consequences
The symposium concluded that understanding the molecular mechanisms of skin aging could lead to better clinical practices and treatments.
research 0871 Skin longevity breakthroughs and targets for cellular age reversal: Sirtuins, key epigenetics regulators
research The emerging role of cellular senescence in amyotrophic lateral sclerosis
Cellular senescence may play a role in ALS, and anti-senescence therapies could be a promising treatment.
research Highlights from the Literature
Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.
research Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy
The substance DMC helps get rid of aging cells by triggering a process that causes cell death, which could treat age-related diseases.
research Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells
Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.
research PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSC senescence and apoptosis
PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.
research 316 Specialized ribosomes in human dermal fibroblast senescence
Specialized ribosomes affect aging in human skin cells.
research Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals
Aged individuals heal wounds less effectively due to specific immune cell issues.