research FGF Family: From Drug Development to Clinical Application
FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.
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90-120 / 1000+ results research Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages
research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction
Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.
research P97: Epidermal growth factor receptor inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege
research Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function
Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.
research Gamma/delta T cells and human skin reactivity to heavy metals
Gamma/delta T cells help defend skin against heavy metals.
research FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling
FGF18 helps hair follicles resist radiation by stopping hair growth cycles.
research CGF therapy: bridging androgenetic alopecia observations to psoriasis treatment via IL-17 pathway
CGF therapy may effectively treat psoriasis by reducing inflammation.
research Epidermal growth factor and transferrin receptor expression in human embryonic and fetal epidermal cells
research IL-17-producing γδ T cells enhance bone regeneration
IL-17-producing γδ T cells help improve bone healing.
research Faculty Opinions recommendation of Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
A substance called FGF9 from certain immune cells can trigger new hair growth during wound healing in mice, but humans may not have the same response due to fewer of these cells.
research Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.
research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17
CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.
research 020 Sphingosine 1-phosphate receptor signalling promotes hair growth and inhibits perifollicular T-cell expansion and immune privilege collapse ex vivo
research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
GLI2 increases follistatin production in human skin cells.
research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege
CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.
research γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection
γδ T cells are crucial for early wound healing after a skin virus infection.
research FGF signaling is required for initiation of feather placode development
FGF signaling is crucial for starting feather development in chicken embryos.
research Melanocortin receptors in fibroblastic cell types of the skin –in vitro and in vivo expression and functional relevance
MC-1R is present in skin cells and may help reduce inflammation.
research Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue1
KGF and its receptor are found in enlarged prostate tissue and KGF strongly increases cell growth.
research Decision letter: IL18 signaling promotes homing of mature Tregs into the thymus
IL-18 signaling helps mature Tregs move into the thymus.
research Immunohistochemical localization of tgf-β in alopecia areata
research Skin γδ T cell subsets have distinct functions in alopecia areata 3844
Different γδ T cell types have unique roles in causing alopecia areata.
research Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
research Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss
research Expression of TGF Beta Receptor 1 in Sika Deer Antler
TGF-β receptor 1 helps deer antlers grow by aiding skin and cartilage cell growth.
research Author response: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells
IL-1 and IL-7 help activate cells that boost hair follicle stem cell growth, aiding wound healing.
research Fgf9 mediates hair follicle neogenesis after wounding through epidermal γδ T cells (초)
Fgf9 helps create new hair follicles after injury through skin T cells.
research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis
CXCR2 in skin cells promotes tumor growth.
research TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells
TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.