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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.

DFMO may help control hair growth and treat cancer.

Testosterone needs to be converted to DHT to reduce stress response in male rats.

The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.

Stressed fibroblasts greatly increase melanin production in hair, skin, and eye cells, mainly due to a growth factor called bFGF.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

Retinol acetate can reduce the harmful effects of the drug benoxaprofen on white blood cells.

Methylation of the 5-AR2 gene may cause resistance to Finasteride in BPH patients.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Deferasirox combined with sorafenib reduces liver cancer risk and lessens treatment side effects.

The compounds tested could potentially treat hair loss and alopecia.

FOXN1 is crucial for thymus development and immune response in Xenopus laevis.

5α-reductase 2 is crucial for stress response in male rats.

The market for these drugs is expected to grow.

Intersex frogs have different brain gene activity related to sex and thyroid hormones.

Finasteride's metabolites were identified, helping understand how the drug is processed in the body.

Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

Lack of 5α-Reductase type 1 can lead to insulin resistance and liver problems.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

15-lipoxygenase helps keep skin healthy by reducing inflammation.

Finasteride reduces heart enlargement and improves heart function.

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

A new compound effectively inhibits human 5α-reductase 1.