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Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men.

6 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research 808 Lichen planus single cell and spatial profiling of cutaneous lichen planus treated with baricitinib

July 2024 in “Journal of Investigative Dermatology”

research Keratosis follicularis spinulosa decalvans: a family study of seven male cases and six female carriers.

41 citations , January 1992 in “Journal of medical genetics”

The study found that males with KFSD had severe skin and eye symptoms, while female carriers had milder symptoms.

research LB1007 Systemic treatment with a KLK5 inhibitor shows efficacy in a murine model of Netherton syndrome

July 2024 in “Journal of Investigative Dermatology”

A KLK5 inhibitor effectively improved skin symptoms in a mouse model of Netherton Syndrome.

research K31 as a novel marker for clear secretory cells in human eccrine sweat glands

32 citations , January 2020 in “Journal of Molecular Histology”

K31 can identify clear secretory cells in human sweat glands.

research Kang'ai Injection Combined with FLO Chemotherapy in the Treatment of Advanced Gastric Cancer:A Clinical Observation of 40 Cases

1 citations , January 2012 in “Zhongguo shiyan fangjixue zazhi”

Kang'ai injection with FLO chemotherapy improves effectiveness and quality of life in advanced gastric cancer patients.

$Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X-ray Powder Diffraction$

research Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X‐ray Powder Diffraction

5 citations , September 2014 in “Journal of Pharmaceutical Sciences”

research COVID-19 vaccination related exacerbations of hair loss in patients with moderate-to-severe alopecia areata on systemic therapy

2 citations , August 2022 in “JAAD case reports”

COVID-19 vaccines may rarely worsen hair loss in people with severe alopecia, but the benefits of vaccination still outweigh this risk.

research Revitalizing Hair Growth: A New Regimen Utilizing Growth Factor Concentrate for Hair Loss Treatment

June 2024 in “Cureus”

GFC injections significantly improved hair growth and quality with minimal side effects.

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma

March 2010 in “Ejc Supplements”

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

research Clinical observation of simultaneous continuous infusion of fluorouracil and disodium folinate combined with oxaliplatin for metastatic colorectal cancer

January 2012 in “Chinese Clinical Oncology”

Disodium folinate can safely and effectively replace calcium folinate in colorectal cancer treatment.

research 96/06363 Flash co-pyrolysis of coal retaining depolymerized polyethylene as radical donor

November 1996 in “Fuel and Energy Abstracts”

Using MALDI-MSI Analysis to Study Distribution of FOL-005, a Potent, Novel Inhibitor of Human Hair Growth, After Subcutaneous Injection in Mice

research 695 Using MALDI-MSI analysis to study distribution of FOL-005, a potent, novel inhibitor of human hair growth, after subcutaneous injection in mice

April 2016 in “Journal of Investigative Dermatology”

FOL-005, a new substance, was found to reduce hair growth without toxicity when injected into skin, suggesting it could be used to treat excessive hair growth.

research Treatment of erythromelanosis follicularis faciei et colli with a 595‐nm pulsed dye laser

November 2023 in “Journal of cosmetic dermatology”

The 595-nm pulsed dye laser effectively reduces symptoms of EFFC with minimal side effects.

research P-13 Some biomechanical properties of human hair keratin (HHK) artificial tendon

December 2000 in “日本組織細胞化学会総会プログラムおよび抄録集”

research Disposition and pharmacokinetics of [14C]finasteride after oral administration in humans.

17 citations , March 1992 in “PubMed”

research Subject Index Vol. 210, 2005

January 2005 in “Dermatology”

research Regulation of a hair follicle keratin intermediate filament gene promoter

39 citations , December 1998 in “Journal of Cell Science”

The LEF-1 binding site enhances gene expression in hair follicles, with other proteins aiding specific regulation.

research IRF2BP2 genes provide new insights into coat type and fiber composition variation in sheep

February 2026 in “Small Ruminant Research”

The IRF2BP2 gene affects sheep fleece quality by influencing fiber traits.

research An accessible pharmacodynamic transcriptional biomarker for notch target engagement

4 citations , February 2016 in “Clinical Pharmacology & Therapeutics”

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

research Detection of human papillomavirus type 56 DNA, belonging to a mucous high-risk group, in hair follicles in the genital area of a woman no longer suffering from viral warts

21 citations , July 2004 in “British Journal of Dermatology”

HPV type 56 can hide in hair follicles even without visible warts.

research MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen¹

37 citations , May 1997 in “The Journal of Clinical Endocrinology & Metabolism”

MK-386 lowers DHT in blood and skin but not in semen.

research Effects of testosterone, dihydrotestosterone and estradiol on growth of human hair outer root sheath keratinocytes in vitro

9 citations , October 1991 in “Archives of Dermatological Research”

Testosterone, DHT, and estradiol significantly affect hair cell growth.

research Serum and hair zinc in cystic fibrosis.

6 citations , July 1980 in “PubMed”

CF patients with growth issues have more zinc in their hair than those with normal growth.

research Measuring steroids in hair opens up possibilities to identify congenital adrenal hyperplasia in developing countries

3 citations , May 2022 in “Clinical endocrinology”

Hair steroid measurement is an effective method to diagnose and monitor CAH in developing countries.

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