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Did you mean Hair Follicle Dystrophy?

GlossaryHair Follicle Dystrophy

condition where hair follicles are structurally abnormal or damaged

Hair Follicle Dystrophy refers to a condition where the hair follicles are structurally abnormal or damaged, leading to impaired hair growth or hair loss. This can result from genetic factors, autoimmune disorders, or external damage such as trauma or harsh chemical treatments. The dystrophy disrupts the normal hair growth cycle, often causing thinning or patchy hair.

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research Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-β Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by “Dystrophic Catagen” Promotion?

18 citations , August 2008 in “Journal of Investigative Dermatology”

17-β estradiol and prednisolone may speed up hair regrowth after chemotherapy.

research Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice

3 citations , January 2021 in “Veterinary dermatology”

A litter of cats had a hair condition similar to a mouse mutation, leading to hair loss and abnormal hair and skin.

research 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa

November 2024 in “Journal of Investigative Dermatology”

Scalp hair follicle cells help protect and heal skin in certain skin conditions.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

19 citations , November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

research 17‐beta estradiol and prednisolone as potential stimulators of hair re‐growth in chemotherapy‐induced human hair follicle damage via ‘dystrophic catagen’ promotion?

June 2008 in “Experimental Dermatology”

17-beta estradiol and prednisolone may help regrow hair damaged by chemotherapy.

research 051 γδ T cells as novel players in alopecia areata pathobiology: Vδ1 + T lymphocytes may recognize “stressed” hair follicle keratinocytes, leading to IFNγ-dependent hair follicle dystrophy and immune privilege collapse

1 citations , April 2016 in “Journal of Investigative Dermatology”

Targeting specific T cells may help treat alopecia areata.

research 441 Anti-melanoma gene signature in dermal sheath fibroblasts from scalp hair follicles in Recessive Dystrophic Epidermolysis Bullosa (RDEB)

November 2024 in “Journal of Investigative Dermatology”

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

6 citations , August 2019 in “PLOS ONE”

Gambogic Amide helps maintain hair color and promotes hair growth.

research Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression

69 citations , May 1997 in “Veterinary Pathology”

The angora mouse mutation causes long hair and hair defects due to a gene deletion.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

HOXC13 is essential for hair and nail development by regulating Foxn1.

research The disrupted balance between hair follicles and sebaceous glands inHoxc13‐ablated rabbits

18 citations , August 2018 in “The FASEB journal”

Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.

The Role of P-Cadherin in Skin Biology and Pathology: Lessons from the Hair Follicle

research The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

15 citations , February 2015 in “Cell & tissue research/Cell and tissue research”

P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.

research 666 Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in follicular dystrophy and primary cicatricial alopecia

April 2018 in “Journal of Investigative Dermatology”

Mutations in Far2 mice cause hair loss due to sebaceous gland issues.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

research Chemotherapy Targets the Hair-Follicle Vascular Network but Not the Stem Cells

45 citations , July 2006 in “Journal of Investigative Dermatology”

Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.

research Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury

12 citations , October 2017 in “Radiation Research”

mTORC1 signaling needed for quick hair follicle recovery after radiation damage.

Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study

research Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study

April 2024 in “Histochemistry and cell biology”

N-acetylcysteine may prevent hair loss caused by chemotherapy.

research LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TAGX-0003 protected hair follicles and reversed alopecia areata in a mouse model.

research Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy

1 citations , June 2022 in “Chinese medical journal/Chinese Medical Journal”

Two new mutations in the CDH3 gene cause hair loss and vision problems in a young girl.

research Hypotrichosis with juvenile macular dystrophy: a case report with molecular study

January 2018

A new genetic mutation was found causing hair and eye issues in a boy.

research The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle

18 citations , March 2016 in “Journal of Investigative Dermatology”

Vitamin D and calcium are essential for normal hair growth.

research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice

31 citations , August 2000 in “Journal of Investigative Dermatology”

Stem cells are key for hair follicle recovery.

research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation

19 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.

research Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard

14 citations , March 2014 in “Experimental and Molecular Pathology”

Sulfur mustard damages hair follicles and sebaceous glands in mice.

research An Experimental Study of Morphofunctional Features of Hair Follicles Early Response in Cyclophosphamide-Induced Alopecia

September 2024 in “Journal of Anatomy and Histopathology”

Miliacin helps damaged hair follicles grow new hair faster.

research Histopathology of Hypotrichosis with Juvenile Macular Dystrophy

19 citations , May 2004 in “The American Journal of Dermatopathology”

The research found that a specific gene mutation causes fewer hair follicles and disrupted hair growth cycles, leading to thin and short hair in people with Hypotrichosis with Juvenile Macular Dystrophy.

research Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles

5 citations , September 2012 in “Journal of Investigative Dermatology”

Scientists can mimic hair disorders by altering genes in lab-grown human hair follicles, but these follicles lack some features of natural ones.

research The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations , February 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research Retinoids Putting the “A” in Alopecia

7 citations , January 2013 in “Journal of Investigative Dermatology”

Vitamin A may influence hair loss conditions like alopecia, but more research is needed to understand how.