March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
March 2021 in “Actas Dermo-Sifiliográficas” The microbiome may be linked to hair loss and could be a target for new treatments.
Encapsulating hair loss drugs in cyclodextrins improves their solubility and reduces scalp irritation.
October 2018 in “InTech eBooks” The gene Foxn1 is important for hair growth, and understanding it may lead to new alopecia treatments.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.
TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.
November 2016 in “Elsevier eBooks” Genetic mutations can affect female sexual development, requiring personalized medical care.
December 2013 in “Research Portal (King's College London)” Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.
February 2010 in “ePrints Soton (University of Southampton)” Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.
January 2009 in “Egyptian Journal of Medical Human Genetics” The study suggests that a specific gene variation and higher gene activity are linked to increased baldness in Egyptian men.
50 citations
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February 2018 in “Biomedicine & pharmacotherapy” Ginseng may help treat cancer and reduce treatment side effects, but more research is needed.
132 citations
,
August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
103 citations
,
January 2011 in “Blood” Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.
89 citations
,
September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
77 citations
,
June 2007 in “PLoS ONE” Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.
52 citations
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May 2015 in “PLOS Genetics” miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.
3 citations
,
February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.
2 citations
,
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.
1 citations
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January 2025 in “Frontiers in Pharmacology” Total glucosides of paeony can help treat skin conditions but need more research for clinical use.
1 citations
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May 2006 in “Expert Opinion on Therapeutic Patents” No FDA-approved treatments for chemotherapy-induced hair loss existed in 2006; more research was needed.
April 2026 in “Laboratory Animal Research” The new Hairless R/J mice model improves imaging for tumor monitoring and cancer therapy evaluation.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
38 citations
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June 2017 in “The Journal of Dermatology” Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences” Metformin may improve acanthosis nigricans by reducing insulin resistance.
532 citations
,
August 2011 in “Journal of the American Academy of Dermatology” Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.
301 citations
,
May 1998 in “Genes & Development” Ets2 gene is crucial for placental development in mice.
182 citations
,
December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.
178 citations
,
August 2016 in “Advances in wound care” New effective scar treatments are urgently needed due to the current options' limited success.
175 citations
,
April 1982 in “Journal of The American Academy of Dermatology” Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.
131 citations
,
March 2004 in “The American journal of pathology” Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.