A Novel Hairless Highly Immunodeficient Mice Model Optimized for In Vivo Imaging

Researchers have developed a novel Hairless Rag2/Jak3 KO mice model, known as Hairless R/J mice, optimized for in vivo imaging. These mice are hairless and lack T, B, and NK cell phenotypes, making them ideal for non-invasive observation of molecular behavior. Compared to traditional Nude mice, Hairless R/J mice have thinner skin and superior optical properties, enhancing imaging capabilities. The model was tested using green fluorescent beads and mCherry-expressing human cholangiocarcinoma cells, as well as Ihara cells for live imaging of tumor growth. This new model is expected to be a valuable tool for noninvasive tumor monitoring and evaluating anticancer therapies.