research Sustainability of functional hair follicle activity: Impact of spatially anchored multifunctional tetrahedral framework nucleic acids
TQC shows promise for better hair regrowth in treating hair loss.
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research 3a-Phenylhexahydropentalene-1,6-dione
A rigid compound with a common structural motif was successfully synthesized.
research Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models
The new compound may be a safer alternative to finasteride for prostate protection.
research Study of Photostability of Finasteride, Diclofenac and Naproxen Through Exposure of Simulated Sunlight and Evaluation of Packaging Photoprotection of These Drugs
Finasteride is more stable in sunlight than Diclofenac and Naproxen.
research P‐30 Use of fipronil for treatment of Lynxacarus radovskyi in outdoor cats in Rio de Janeiro (Brazil)
Fipronil effectively treats Lynxacarus radovskyi in outdoor cats.
research 43755 Rapid Reduction and Strict Complete Response in Itch With Oral Difelikefalin in Subjects With Notalgia Paresthetica and Moderate-to-Severe Pruritus
Oral difelikefalin significantly reduces itch in notalgia paresthetica.
research Monocyclic Aromatic Compounds
Monocyclic aromatic compounds are important for developing various drugs and treatments.
research Novel synthesis of nicotinamide derivatives of cytotoxic properties
Newly made nicotinamide compounds could potentially treat cancer.
research Finasteride
research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen
Clofazimine may be effective for treating ashy dermatosis.
research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones
The research created new azasteroids and pseudoazulenyl nitrones, which could be useful in medicine.
research Screening of drugs with potential antifungal activity for repurposing in the treatment of cryptococcosis.
Certain antiparasitics and antidepressants show promise for treating cryptococcosis, especially when combined with fluconazole.
research New Synthesis of Finasteride
A new method to make Finasteride is more cost-effective and yields 16%.
research Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma
The new formulation greatly improved quercetin absorption in rats.
research Sunscreen remanence on the skin: a noninvasive real time in vivo spectral analysis assessing the quenching of specular ultraviolet A light reflectance
Sunscreens with UVA blockers effectively reduce skin fluorescence for several hours.
research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.
research 13C-NMR study of 4-azasteroids in solution and solid state
4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
research Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents
Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.
research Synthesis, Crystal Structure and Supramolecular Features of Novel 2,4-Diaminopyrimidine Salts
The salts have diverse molecular packing with significant hydrogen interactions.
research Experimental and theoretical studies on the interaction of finasteride with chitosan-based nanoniosomes
The new finasteride delivery system using chitosan-based nanoniosomes shows promise for prostate cancer prevention.
research Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review
Taxifolin, found in onions and milk thistle, has health benefits but needs more research for safe use.
research Preparation, Characterization and Molecular Docking Study of some New Pyrazole Derivatives Derived from 2-Mercaptobenzothiazole.
New pyrazole derivatives may help treat hair loss, but more testing is needed.
research Fluorine-Induced Apoptosis and Lipid Peroxidation in Human Hair Follicles In Vitro
research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes
Researchers made two new compounds that could be used for medicine.
research Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model
Terbinafine HCl nail solutions with DDAIP HCl are more effective than current treatments for nail infections.
research Isolation and Structural Characterization of Finasteride Degradation Products by Preparative HPLC, HRMS, and NMR
This study investigates the degradation profile of finasteride, a drug used for benign prostatic hyperplasia and androgenetic alopecia, under stress conditions. Using LC–MS, three degradation products were identified under acidic conditions, with minimal degradation in alkaline and oxidative environments. The degradation products were isolated and analyzed using preparative HPLC, HRMS, and NMR spectroscopy. The study revealed that the degradation process of DP-1 involved cleavage of the tert-butyl amide and addition of water across the alkene moiety. The structure of DP-1 was established through various spectroscopic techniques, and it, along with other degradation products, was found to be previously undescribed. These findings enhance the understanding of finasteride's degradation chemistry, aiding impurity profiling, stability studies, and quality control of its formulations.
research FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models
The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.
research Preparation and Characterization of Rutin-loaded Nanophytosomes
Nanophytosomes can improve the delivery and effectiveness of herbal medicines like Rutin.
research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.