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GlossaryGABA receptor

protein in the brain that inhibits neuronal activity

A GABA receptor is a protein in the brain that responds to the neurotransmitter gamma-aminobutyric acid (GABA). It plays a crucial role in reducing neuronal excitability throughout the nervous system. There are two main types: GABA(A) receptors, which are ion channels that allow chloride ions to enter the neuron, leading to inhibition, and GABA(B) receptors, which are G-protein-coupled receptors that influence neuronal activity through secondary messenger systems.

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research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

33 citations , December 2015 in “Neuroendocrinology”

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Brain Allopregnanolone Induces Marked Scratching Behavior in Diet-Induced Atopic Dermatitis Mouse Model

research Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model

6 citations , February 2019 in “Scientific reports”

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress

research Neurosteroid Synthesis-Mediated Regulation of GABA_{Asub>Receptors: Relevance to the Ovarian Cycle and Stress}

238 citations , February 2007 in “Journal of Neuroscience”

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility

research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA_{Asub>Receptor Function and Seizure Susceptibility}

269 citations , May 2002 in “Journal of Neuroscience”

Stress increases neurosteroids that help prevent seizures.

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors

research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_{Asub>Receptors}

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

research Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy

30 citations , February 2003 in “Annals of Neurology”

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

research Implications of neuroimaging for the treatment of epilepsy

2 citations , February 2003 in “Annals of Neurology”

Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.

GABAA Receptor Modulation by Neurosteroids in Models of Temporal Lobe Epilepsies

research GABA_{Asub>receptor modulation by neurosteroids in models of temporal lobe epilepsies}

40 citations , December 2012 in “Epilepsia”

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

research Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction

15 citations , June 2014 in “Behavioural Brain Research”

Neurosteroids may help metyrapone reduce cocaine addiction.

research Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

6 citations , August 2019 in “PLOS ONE”

Gambogic Amide helps maintain hair color and promotes hair growth.

research Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

59 citations , April 2016 in “Breast Cancer Research and Treatment”

Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.

research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol

34 citations , June 2011 in “Alcoholism: Clinical and Experimental Research”

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

Changes in Expression and Function of Extrasynaptic GABA A Receptors in the Rat Hippocampus During Pregnancy and After Delivery

research Changes in Expression and Function of Extrasynaptic GABA_{Asub>Receptors in the Rat Hippocampus during Pregnancy and after Delivery}

86 citations , February 2009 in “Journal of Neuroscience”

Pregnancy increases certain GABA_A receptors in rat brains, influenced by steroid levels.

research Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats

4 citations , November 2018 in “Journal of pharmacological sciences”

Mild exercise reduces pain in older rats through a brain chemical, while intense exercise reduces pain in all rats through a different pain-blocking process.

Angelica Gigas Nakai (Korean Dang-Gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy: Active Phytochemicals and In Vivo Molecular Targets

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

2 citations , January 2025 in “Pharmaceutical Research”

Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.

research How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap

3 citations , October 2010 in “Epilepsy Currents”

Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.

research Neurosteroids on the Epilepsy Chessboard—Keeping Seizures in Check

October 2010 in “Epilepsy Currents”

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations , December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

research Which chemicals should be grouped together for mixture risk assessments of male reproductive disorders?

40 citations , September 2019 in “Molecular and Cellular Endocrinology”

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

research Drug repositioning using in silico compound profiling

24 citations , December 2009 in “Future Medicinal Chemistry”

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

research The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease

15 citations , January 2017 in “Experimental Neurology”

Finasteride reduces movement issues in Parkinson's disease rats.

research Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo

10 citations , January 2017 in “Skin Pharmacology and Physiology”

Finasteride may cause vitiligo, sexual issues, and depression; better treatments and predicting side effects needed.

Endocrinology and Aesthetic Medicine Edition X

research Endocrinologia e Medicina Estética Ed. X

February 2026 in “Editora Pasteur eBooks”

A comprehensive, personalized approach is needed for treating female pattern hair loss and obesity, involving multiple medical disciplines and lifestyle changes.

research Hormones and Absence Epilepsy☆

January 2017 in “Elsevier eBooks”

Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.

research The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating

49 citations , September 2015 in “Psychoneuroendocrinology”

5α-reductase affects dopamine receptors linked to sensorimotor gating, which may help understand disorders like schizophrenia.

research International Journal of KIU

July 2022 in “International journal of KIU”

Genetics influence opioid addiction risk, diet affects COVID-19 severity, Aerva lanata may harm kidneys, some plants fight fungi and cancer, and nursing students need better contraceptive knowledge.

research Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats

27 citations , April 2007 in “European Journal of Pharmacology”

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.