research Innovations in skin microphysiological systems for nonclinical testing and FDA modernization
New technologies replicate human skin for testing without animals.
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810-840 / 1000+ resultsresearch Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
Lifestyle changes and environmental strategies can help address declining testosterone levels.
research Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery
Advancements in regenerative science and longevity research can improve healthspans, but must be balanced with ethics and safety.
research Regenerative Versus Nonregenerative Repair of the Renal Medulla After Reversal of Ureteral Obstruction
Regenerative repair is essential to prevent long-term kidney function issues after obstruction.
research Characterisation of Four New Genes in the Ovine KAP19 Family
Four new genes related to sheep wool were discovered, showing genetic diversity.
research Diagnosis of polycystic ovaries syndrome: establishment of reference values of nine hormones on Maglumi X- 8
Reference values for nine hormones were established to help diagnose PCOS.
research Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders
Psoriasis involves immune and genetic factors, and understanding these can improve treatments.
research Current Insight of Peptide-Based Hydrogels for Chronic Wound Healing Applications: A Concise Review
Peptide-based hydrogels are promising for healing chronic wounds effectively.
research The Who’s, What’s, and “Y”s: Y Sex Chromosome Loss and Methylation for Analysis in Male Aging and Mortality and Forensic Science Applications
Understanding the Y chromosome is key to male health, aging, and developing diagnostic tools.
research The future in the litter bin – bioconversion of food waste as driver of a circular bioeconomy
Turning food waste into useful products is key for a sustainable economy.
research Metabolic Engineering of Microorganisms to Produce L-Aspartate and Its Derivatives
Scientists can use engineered microbes to make L-aspartate and related chemicals, but there's still room to improve their efficiency.
research Endocrinology
The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.
research New frontiers in CRISPR/Cas9 delivery systems delivery for gene editing
Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.
research A Profuse Pipeline of Promising Options
The document concludes that significant investment in agricultural innovation is necessary to achieve global food security and nutrition.
research Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis
Type XVII collagen helps control skin cell growth and may have anti-aging effects.
research Decision letter: Type XVII collagen coordinates proliferation in the interfollicular epidermis
Type XVII collagen may help prevent skin aging.
research Recent Updates of the CRISPR/Cas9 Genome Editing System: Novel Approaches to Regulate Its Spatiotemporal Control by Genetic and Physicochemical Strategies
CRISPR/Cas9 has improved precision and control but still faces clinical challenges.
research Mind the Gap: A Solution to the Robustness Problem of Turing Patterns Through Patterning Mode Isolation
Pattern mode isolation improves the reliability and predictability of Turing patterns.
research Sparse haplotype-based fine-scale local ancestry inference at scale reveals recent selection on immune responses
Recent selection on immune response genes was identified across seven ethnicities.
research BJD Editor's Choice
Some Greek melanoma patients have gene mutations linked to increased cancer risk, a new color feature helps diagnose melanoma, the incidence of a skin condition in the Netherlands is rare, and a gene possibly affects male-pattern baldness.
research Kawasaki disease: an update
Early treatment with immunoglobulin and aspirin reduces heart complications in children with Kawasaki disease.
research Development of polycystic ovary syndrome: involvement of genetic and environmental factors
PCOS is caused by both genetics and environmental factors like diet and obesity.
research Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes
Nanozymes show promise for effective and safe cancer treatment.
research From skin microrelief to wrinkles. An area ripe for investigation
Wrinkles form due to structural skin changes and vary in type and treatment response.
research Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination
The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
research The Polycystic Ovary Syndrome Evolutionary Paradox: a Genome-Wide Association Studies–Based, in silico, Evolutionary Explanation
The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.
research Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review
Autoimmune liver diseases are likely linked to certain skin conditions like vitiligo and psoriasis.
research Sperm aneuploidy in infertile male patients: a systematic review of the literature
Infertile men are more likely to produce sperm with abnormal chromosome numbers, which can affect pregnancy success and embryo health.
research Contrasting Narratives of Race and Fatness in Covid-19
Racial minorities faced more Covid-19 blame due to anti-fatness and structural racism.
research sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome
PCOS involves immune and genetic factors, with key roles for T cells and specific genes.