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research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy?

September 2006 in “Experimental Dermatology”

Targeting multiple pathways and understanding genetic mutations are crucial for effective melanoma therapy.

research 479 Transcriptomics identifies potential novel therapeutic targets in androgenetic alopecia

April 2017 in “Journal of Investigative Dermatology”

Found new possible treatments for hair loss.

Nevoid Basal Carcinoma Syndrome (Gorlin Syndrome) and Pronounced Androgenic Alopecia in a Woman with a Novel Mutation p.Leu1159fsx32 in the PTCH Gene

research Nevoid basal carcinoma syndrome (Gorlin syndrome) and pronounced androgenic alopecia in a woman with a novel mutation p.Leu1159fsx32 in the PTCH gene

1 citations , September 2011 in “Journal of Dermatology”

A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.

research Repurposing of Various Current Medicines as Radioprotective Agents

April 2022 in “Anti-cancer agents in medicinal chemistry”

Some existing medicines show promise as safe treatments to protect against the side effects of radiation therapy.

research 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile

April 2023 in “Journal of Investigative Dermatology”

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

9 citations , March 2018 in “International journal of molecular sciences”

Allopregnanolone changes gene expression in glioblastoma cells.

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

Glibenclamide slows breast cancer cell growth by stopping cell division.

research The postnatal offspring of finasteride-treated male rats show altered ERα and PCNA expression in the liver

July 2025 in “Reproductive Biology”

Finasteride use in male rats may harm their male offspring's liver function.

research QS8: Analysis of the Whole Transcriptome in Breast Cancer Patients Undergoing Radiotherapy and Breast Reconstruction

July 2021 in “Plastic and reconstructive surgery. Global open”

Radiation therapy in breast cancer patients changes gene expression related to DNA damage, fibroblast growth, and hair follicle development, which could help improve treatment for radiation-induced fibrosis.

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