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Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells

4 citations , September 2024 in “Development”

Researchers converted human embryonic stem cells into trophoblast stem cells using specific transcription factors.

research Sacituzumab Govitecan-Hziy (Trodelvy™)

3 citations , April 2021 in “Oncology Times”

Trodelvy™ helped some patients with advanced breast cancer, but had side effects.

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations , December 2011 in “American Journal Of Pathology”

A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.

research Depletion of Gsdma1/2/3i> alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase
124 citations , July 1997 in “Journal of Biological Chemistry”

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

research Hutchinson-Gilford Progeria Syndrome: Premature Aging
April 2026

RNA-based treatments show promise for managing Hutchinson-Gilford Progeria Syndrome.

research Hutchinson-Gilford progeria syndrome - A brief introduction
2 citations , June 2018 in “International Journal of Pharmacological Research”

Hutchinson-Gilford Progeria Syndrome caused rapid aging due to a genetic mutation, with treatments to manage symptoms.

research DNMT3B -579G>T POLYMORPHİSM AND THE RİSK OF COLORECTAL CANCER IN AZERBAİJAN POPULATİON
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)”

The DNMT3B -579G>T polymorphism may increase the risk of colorectal cancer.

research The Region Coding for the Helix Termination Motif and the Adjacent Intron 6 of the Human Type I Hair Keratin Gene hHa2 Contains Three Natural, Closely Spaced Polymorphic Sites
6 citations , March 1996 in “Journal of Investigative Dermatology”

research Novel D323G mutation of DSG4i> gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix
8 citations , July 2015 in “International Journal of Dermatology”

A new DSG4 gene mutation causes hair defects in a young girl.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature
15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice
58 citations , July 2005 in “Molecular and Cellular Biology”

A specific gene segment can make mouse skin cells glow, helping study hair growth and gene effects.

research NUDT15i>,FTOi>, andRUNX1i>genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases
40 citations , January 2017 in “Intestinal Research”

Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.

research Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
65 citations , February 2011 in “Molecular cancer therapeutics”

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

research β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain
67 citations , December 2009 in “Stem Cells”

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

research Hepatocyte growth factor combined with adenosine deaminase as biomarker for diagnosis of tuberculous pleural effusion
4 citations , July 2023 in “Frontiers in Microbiology”

HGF combined with ADA is highly accurate for diagnosing tuberculous pleural effusion, especially in younger females.

research Scraggly, a new hair loss mutation on mouse Chromosome 19
14 citations , September 1999 in “Mammalian genome”

The scraggly mutation causes hair loss and skin defects in mice.

research Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice
3 citations , January 2014 in “International Journal of Medical Sciences”

Mice with human chymase had a higher death rate when exposed to a toxin compared to normal mice.

research Intraretinal variation in disease severity in the Oat mouse model of gyrate atrophy
April 2025 in “Experimental Eye Research”

The Oat mouse model shows mild retinal degeneration, useful for testing treatments.

research Activation and regulation of the granulation tissue derived cells with stemness-related properties
14 citations , April 2015 in “Stem Cell Research & Therapy”

Granulation tissue-derived cells can aid wound healing and serve as an alternative source of stem cells for tissue repair.

research The Fate of Trichohyalin
135 citations , October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle
1 citations , February 1991 in “Journal of Biological Chemistry”

research Independent DSG4 frameshift variants in cats with hair shaft dystrophy
December 2021 in “Molecular genetics and genomics”

Cats with abnormal hair had DSG4 gene changes causing hair problems.

research Contrast enhanced phototrichogram (CE-PTG): an improved non-invasive technique for measurement of scalp hair dynamics in androgenetic alopecia–validation study with histology after transverse sectioning of scalp biopsies.
12 citations , August 2001 in “PubMed”

CE-PTG is a better method for analyzing hair growth in androgenetic alopecia.

research Matriptase: Potent Proteolysis on the Cell Surface
165 citations , January 2006 in “Molecular Medicine”

Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.

research Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs
34 citations , August 2016 in “Scientific Reports”

Blocking TGFβ-RI signaling enhances surface ectoderm differentiation from human stem cells.

research Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling
5 citations , May 2024 in “Developmental Cell”

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
372 citations , December 2004 in “Nature Genetics”

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research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

research Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells

research Sacituzumab Govitecan-Hziy (Trodelvy™)

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

research Depletion of Gsdma1/2/3i> alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

research Hutchinson-Gilford Progeria Syndrome: Premature Aging

research Hutchinson-Gilford progeria syndrome - A brief introduction

research DNMT3B -579G>T POLYMORPHİSM AND THE RİSK OF COLORECTAL CANCER IN AZERBAİJAN POPULATİON

research The Region Coding for the Helix Termination Motif and the Adjacent Intron 6 of the Human Type I Hair Keratin Gene hHa2 Contains Three Natural, Closely Spaced Polymorphic Sites

research Novel D323G mutation of DSG4i> gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

research Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice

research NUDT15i>,FTOi>, andRUNX1i>genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

research Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

research β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain

research Hepatocyte growth factor combined with adenosine deaminase as biomarker for diagnosis of tuberculous pleural effusion

research Scraggly, a new hair loss mutation on mouse Chromosome 19

research Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice

research Intraretinal variation in disease severity in the Oat mouse model of gyrate atrophy

research Activation and regulation of the granulation tissue derived cells with stemness-related properties

research The Fate of Trichohyalin

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle

research Independent DSG4 frameshift variants in cats with hair shaft dystrophy

research Contrast enhanced phototrichogram (CE-PTG): an improved non-invasive technique for measurement of scalp hair dynamics in androgenetic alopecia–validation study with histology after transverse sectioning of scalp biopsies.

research Matriptase: Potent Proteolysis on the Cell Surface

research Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

research Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity