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GlossaryGlucocorticoid Resistance

condition where tissues are less responsive to steroid hormones

Glucocorticoid Resistance, also known as Steroid Resistance, is a condition where the body's tissues are less sensitive or unresponsive to glucocorticoids, which are a type of steroid hormone used to reduce inflammation and regulate immune responses. This can make it difficult to treat conditions like asthma, rheumatoid arthritis, and certain autoimmune diseases, as the usual doses of glucocorticoids become less effective.

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A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Primary Generalized Glucocorticoid Resistance and Hypersensitivity

48 citations , January 2011 in “Hormone Research in Paediatrics”

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

research Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance

15 citations , April 2016 in “Hormones”

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

research Generalised Glucocorticoid Resistance

1 citations , January 2008 in “touchREVIEWS in Endocrinology”

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

research Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

December 2016 in “Springer eBooks”

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

research Generalised Glucocorticoid Resistance

January 2008 in “US endocrinology”

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Glucocorticoid Resistance Syndrome in Two Patients With Diverse Genotype

research Glucocorticoid Resistance Syndrome in 2 Patients With Diverse Genotype

January 2025 in “JCEM Case Reports”

Diagnosing and managing Glucocorticoid Resistance Syndrome is complex due to genetic differences and varied symptoms.

research The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene

December 2023 in “JCEM case reports”

A new gene variant causes glucocorticoid resistance in a mother and son.

research LBODP010 A Case of Glucocorticoid Resistance Syndrome

November 2022 in “Journal of the Endocrine Society”

The patient likely has Chrousos syndrome, a rare condition causing insensitivity to glucocorticoids, requiring high-dose dexamethasone treatment.

research Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes

15 citations , April 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

research An overview of animal models induced by glucocorticoids

September 2023 in “Physiology and Pharmacology”

Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.

research 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

93 citations , September 2014 in “Diabetes”

Lack of 5α-Reductase type 1 can lead to insulin resistance and liver problems.

research Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid

19 citations , September 2010 in “The American journal of pathology”

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.

research Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene

94 citations , April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

research Chrousos syndrome: from molecular pathogenesis to therapeutic management

47 citations , February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

research Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

7 citations , December 2011 in “InTech eBooks”

Glucocorticoid and mineralocorticoid therapy effectively manage Congenital Adrenal Hyperplasia symptoms but have limitations.

research Mucocutaneous Manifestations of Endocrine Disorders

November 2013 in “John Wiley & Sons, Ltd eBooks”

Skin symptoms can indicate endocrine disorders and have various treatments.

research Acne-associated syndromes: models for better understanding of acne pathogenesis

January 2012 in “Yearbook of Dermatology and Dermatologic Surgery”

Studying acne-related syndromes helps us understand acne causes and can lead to new treatments.

research [Hirsutism and hypertrichosis in adults: investigations and treatment].

3 citations , May 2002 in “PubMed”

The document concludes that treatment for excessive hair growth depends on the cause, with options including hair removal methods and medications like anti-androgens or insulin-sensitizing drugs.

research The Polycystic Ovary Syndrome and Acne

2 citations , January 2014 in “Springer eBooks”

Polycystic Ovary Syndrome (PCOS) often leads to severe acne, and lifestyle changes and hormonal treatments can help manage it.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Steroid-Free Monotherapy with Tofacitinib in Severe Therapy-Resistant Alopecia: A Retrospective Analysis

research A Real-World Study of Steroid-Free Monotherapy with Tofacitinib in Severe and Therapy-Recalcitrant Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Cases: A Retrospective Analysis

November 2023 in “Indian Dermatology Online Journal”

Tofacitinib was effective for severe, treatment-resistant hair loss without side effects.

research Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells

34 citations , March 2007 in “Biochemical and Biophysical Research Communications”

Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.

research Hormone therapy in acne

24 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide

2 citations , November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia

2 citations , September 2019 in “Acta Cardiologica”

Women with non-classic congenital adrenal hyperplasia have higher risk for heart and metabolic problems.

research Androgen receptor-mediated gene activation in prostate cancer cells

1 citations , September 2010 in “UEF eRepo (University of Eastern Finland)”

Androgen receptors help prostate cancer cells grow and resist drugs.

research Hormonal treatment of acne vulgaris: an update

46 citations , September 2016 in “Clinical, Cosmetic and Investigational Dermatology”

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

research Nail lichen planus in a patient with alopecia totalis

January 2015 in “Dermatology online journal”

A man with total hair loss also developed a rare nail condition, likely due to autoimmune issues.