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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

research Molecular studies of the Medicago truncatula MtAnn3 gene involved in root hair deformation

4 citations , February 2012 in “Chinese Science Bulletin”

The MtAnn3 gene affects root hair growth and is influenced by cytokinin.

research Higher Levels of Hair Ethyl Glucuronide in Patients with Decreased Kidney Function

36 citations , June 2012 in “Alcoholism Clinical and Experimental Research”

People with decreased kidney function have higher levels of ethyl glucuronide in their hair.

The Compatibility of Bacillus Thuringiensis Cry Protein-Solubilizing Buffers with the Droplet Feeding Method in Fall Armyworm Larvae

research The compatibility of Bacillus thuringiensis Cry protein-solubilizing buffers with the droplet feeding method in fall armyworm larvae

August 2019 in “Journal of Invertebrate Pathology”

Thymosin beta 4 protects cells from damage by blocking a harmful microRNA and boosting a protective gene.

research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

3 citations , January 2024 in “Frontiers in Endocrinology”

Androgens can affect glucocorticoid signaling in specific mouse brain areas.

research 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes

43 citations , August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

research Ultrastructural visualization of cross-linked protein features in epidermal appendages

43 citations , July 1994 in “Journal of Cell Science”

Cross-linked proteins help maintain the structure of hair, feathers, and hagfish teeth.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss

9 citations , January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

Pair Annotation: Adaptation of Pair Programming to Corpus Annotation

research Pair Annotation: Adaption of Pair Programming to Corpus Annotation

4 citations , July 2012 in “Linguistic Annotation Workshop”

Root hairs in barley improve growth and zinc uptake in zinc-deficient soil.

research NEW FORMULATIONS: Glatiramer acetate

October 2004 in “Australian Prescriber”

Lifestyle changes are more effective than medication for managing PCOS-related risks.

research Screening of steroid 5-reductase inhibitory activity and total phenolic content of Thai plants

April 2011 in “Journal of Medicinal Plants Research”

Ocimum basilicum L. and red Oryza sativa L. may help with hair loss and prostate issues.

research The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function

1 citations , January 2013

Glucosylceramides are essential for healthy skin and proper wound healing.

research In silico screening of effective inhibitor of 5α-reductase type 1 for androgenic alopecia treatment

1 citations , December 2021 in “Natural Product Research”

β-sitosterol and brassicasterol may help treat hair loss.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region

2 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damaged hair follicle stem cells in transgenic mice.

research Enzyme Inhibitory Activity of Certain Vegetables Indigenous in Iran as Potential Antiandrogens

January 2018 in “Journal of Food Biosciences and Technology”

Garlic and fenugreek may help treat hair loss.

research Role of Inositol in Alopecia of Rats Fed Sulfasuxidine.

25 citations , January 1944 in “Experimental Biology and Medicine”

Inositol prevents hair loss and improves health in rats.

research Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes In Vitro

24 citations , February 2007 in “Hormone and metabolic research”

The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.