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The endocannabinoid system affects oil production and inflammation in skin cells.

The conclusion is that metformin is a first-line treatment for PCOS, particularly for restoring ovulation and increasing pregnancy rates, with other treatments depending on specific symptoms.

Serenoa repens (saw palmetto) may cause side effects like hot flashes in children and needs more research for safety in pediatric use.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

A postmenopausal woman's excessive hair growth and hair loss were due to a non-cancerous ovarian condition, treated successfully with surgery.

The April 2014 issue of "Fertility and Sterility" discussed various reproductive health topics, including hormone therapy benefits, sperm and genetic factors in male infertility, and the link between PCOS and diabetes.

PCOS increases the risk of heart disease and type 2 diabetes in women.

Testosterone therapy can help postmenopausal women with low sexual desire but needs more safety research and should be used with estrogen therapy.

Testosterone therapy can help with androgen deficiency in women but should be used with caution and monitoring due to potential risks.

Testosterone therapy can help improve sexual function, mood, and bone density in women with low androgen levels, but more research is needed on long-term safety.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Finasteride doesn't affect bone density in male rats.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Finasteride significantly reduces hair growth in women with idiopathic hirsutism.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.

Finasteride doesn't affect bone density in male rats.