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A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

A 20-year-old woman was found to have a rare ovarian tumor causing symptoms like acne and a low-pitched voice, which disappeared after the tumor was removed.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

A genetic defect causes males in some Mediterranean populations to be born with ambiguous genitalia and develop male traits at puberty.

Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.

A young woman's rare ovarian tumor was successfully removed, improving her hormonal symptoms.

A rare ovarian tumor caused high male hormone levels, but surgery fixed it.

Mouse genital development depends on male or female hormones for specific features.

Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.

DHT is crucial for urethral formation, and its disruption can affect masculinization and lead to hypospadias.

A 23-year-old woman's missed periods were caused by a rare genetic disorder treated with hormone patches.

After tumor removal, the woman regained normal hormone levels, menstruated, and had a healthy baby.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

Male children's genital development issues can be caused by genetic mutations or environmental factors affecting hormone action.

A boy's early puberty caused by a testicular tumor returned to normal after surgery.

A rare ovarian tumor in a 2-year-old girl was successfully removed, normalizing her hormone levels.

A rare ovarian tumor can occur without causing male-like symptoms.

A woman's small ovarian tumor causing high androgen levels was missed by several scans but found during surgery.

A 68-year-old woman developed male traits due to a tumor in her ovary, which was removed, returning her hormone levels to normal.

Longer anogenital distance may indicate a higher chance of having polycystic ovary syndrome, and measuring this distance along with hormone levels could improve diagnosis.

The 18-year-old girl likely has a condition called müllerian agenesis, which caused her to not have a uterus and experience no menstrual periods.

Parental support and gender-affirming care are crucial for the mental health of transgender adolescents.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Minoxidil treatment improves heart defects in a DiGeorge syndrome model.

Removing both ovaries may better treat increased male hormone levels and related symptoms in postmenopausal women when hormone therapy doesn't work.

Surgical removal of a rare ovarian tumor improved symptoms and hormone levels in a postmenopausal woman.

A rare, non-cancerous ovarian tumor was successfully treated with surgery, improving the patient's symptoms.

Women with polycystic ovary syndrome tend to have a longer anogenital distance.

Reducing granulosa cell pyroptosis may improve oocyte maturation in PCOS.