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GlossaryGrowth Factor Secretion

cells release proteins that regulate growth and repair processes

Growth Factor Secretion refers to the process by which cells release proteins known as growth factors into their surrounding environment. These growth factors play a crucial role in regulating various cellular processes, including cell growth, division, and differentiation, which are essential for tissue repair and regeneration. In the context of hair biology, growth factor secretion can influence hair follicle development and the hair growth cycle, potentially impacting conditions like alopecia.

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Variability in Secretion of Growth Factors by Platelets Is Intrinsic to Alopecia Patients Undergoing Platelet-Rich Plasma Therapy

research 832 Variability in secretion of growth factors by platelets is intrinsic to alopecia patients undergoing platelet-rich plasma therapy

June 2020 in “Journal of Investigative Dermatology”

Hair growth treatment results vary because each patient's platelets release different levels of growth factors.

research RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells

6 citations , October 2024 in “Frontiers in Bioengineering and Biotechnology”

A special hydrogel helps stem cells heal wounds better by boosting growth factors.

research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

research Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial growth factor secretion

30 citations , March 2008 in “Wound Repair and Regeneration”

Estrogen affects scalp cell types differently, enhancing some wound healing processes.

research Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease

38 citations , January 2017 in “Mediators of Inflammation”

Platelet-released growth factors can reduce inflammation in joint disease.

Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

research Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway

June 2023 in “Italian Journal of Medicine”

Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research In vitro effects of baicalin on the growth of human hair follicles and secretion of vascular endothelial growth factor by human dermal papilla cells

1 citations , January 2007 in “Chinese Journal of Dermatology”

Baicalin may help hair growth by increasing VEGF secretion.

research Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion

1 citations , July 2024 in “British Journal of Dermatology”

Inhibiting certain proteins harms hair follicle immunity and increases IL-33, affecting hair health.

research effects Of Low-level Laser Therapy (lllt) On Dermal Papilla Cell Proliferation And Insulin-like Growth Factor-1 (igf-1) Secretion From Balding Hair Follicles : #lb12

April 2014

research Fibroblast‐derived growth factors and exosomes as cosmeceuticals

October 2023 in “Dermatological reviews”

Fibroblast-derived growth factors and exosomes can significantly improve skin aging.

research THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES

January 2026 in “International Journal of Applied Pharmaceutics”

A 10% MSC secretome hair tonic best promotes hair growth in alopecia.

research Stem cell secretome as a new booster for regenerative medicine

54 citations , August 2019 in “Bioscience trends”

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

research Mesenchymal Stem Cell Secretome for Dermatology Application: A Review

26 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

The secretome from mesenchymal stem cells shows promise for treating skin conditions and improving skin and hair health, but more research is needed.

research Secretome of Mesenchymal Stromal Cells as a Possible Innovative Therapeutic Tool in Facial Nerve Injury Treatment

2 citations , January 2023 in “BioMed Research International”

The secretome from mesenchymal stromal cells shows promise for improving facial nerve injury treatment.

Efficacy of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract on Hair Growth and Anchorage in Human Dermal Papilla Cells

research 721 Efficacy of silybum marianum extract, manganese PCA and lespedeza capitata extract on hair growth and anchorage in human dermal papilla cells

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help with hair growth and anchorage, potentially aiding in hair loss treatment.

research Heterogeneity in amount of growth factors secreted by platelets in platelet‐rich plasma samples from alopecia patients

8 citations , August 2020 in “Experimental dermatology”

PRP therapy for alopecia shows inconsistent results due to natural variability in growth factor secretion by platelets.

Induction of Hair Growth in Hair Follicle Cells and Organ Cultures Upon Treatment with 30 kHz Frequency Inaudible Sound via Cell Proliferation and Antiapoptotic Effects

research Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects

January 2022 in “Biomedical Reports”

Inaudible sound at 30 kHz can boost hair growth and decrease hair loss by promoting cell growth and reducing cell death in hair follicles.

research Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

26 citations , December 2016 in “Pharmacology & Therapeutics”

New drugs for heart disease may be developed from molecules secreted by stem cells.

research A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

8 citations , July 2022 in “International Journal of Molecular Sciences”

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

Secretome of Bovine Umbilical Vein Endothelial Cells Promotes Wound Healing Regeneration in Second Degree Rat Model Burn Injury

research Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury

January 2023 in “Open veterinary journal”

Cow blood vessel cell secretions helped heal rat burn wounds and may treat burns and hair loss.

research Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells

May 2026 in “Journal of Tissue Engineering”

A new treatment using cell secretions can regrow hair better than minoxidil.

research Limbal Mesenchymal Stem Cell Secretome as Potential Adjuvant Therapy for Ocular Alkali Injury

February 2022

Limbal Mesenchymal Stem Cell Secretome might help heal eye injuries by reducing inflammation and promoting tissue repair.

research ROOT HAIR DEFECTIVE SIX‐LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth

75 citations , July 2016 in “New phytologist”

The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.

research Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β‐catenin signalling

12 citations , October 2019 in “Experimental Dermatology”

Boehmite promotes hair growth by stimulating key cells and pathways.

research ISX-9 Promotes KGF Secretion From MSCs to Alleviate ALI Through NGFR-ERK-TAU-β-Catenin Signaling Axis

2 citations , December 2023 in “Stem Cells Translational Medicine”

ISX-9 helps stem cells heal lung injury better by boosting growth factor secretion.

research Adipose-derived Stem Cell Secretome and Its Potential Role in the Treatment of Androgenetic Alopecia

October 2021 in “Plastic and reconstructive surgery. Global open”

Adipose-derived stem cells may help treat hair loss.

research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1𝛼 in Adipose Derived Stem Cells (ADSCs) Secretome in Androgenetic Alopecia

January 2021

Higher levels of certain proteins in hair loss areas may help understand and treat hair loss.

research Influence of interleukin‐1α on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells

14 citations , September 2006 in “Experimental Dermatology”

Interleukin‐1 α reduces androgen receptor levels and increases certain cytokines in human scalp cells.

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.