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research High-sulfur protein deficient human hair: clinical aspects and biochemical study of two unreported cases of a variant type of trichothiodystrophy

11 citations , January 1989

Two patients had a unique form of trichothiodystrophy with reduced high-sulfur proteins in their hair.

research The topical penta-peptide Gly-Pro-Ile-Gly-Ser increases the proportion of thick hair in Japanese men with androgenetic alopecia

3 citations , March 2016 in “Journal of Cosmetic Dermatology”

GPIGS peptide increases thick hair growth in balding Japanese men.

research 217 The adenosine-generating ecto-enzyme CD73 regulates human hair growth

August 2016 in “Journal of Investigative Dermatology”

The enzyme CD73 helps control human hair growth and could be targeted to treat hair growth disorders.

A Hairy Situation: PADIs in Regeneration and Alopecia

research A Hairy Cituation – PADIs in Regeneration and Alopecia

5 citations , December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

research Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

14 citations , June 2012 in “Stem Cells”

TACE/ADAM17 is essential for maintaining healthy hair and hair follicle stem cells.

research Cyclic Nucleotides and the Mediation of Melatonin-induced Inhibition of Melanogenesis in Mammals

1 citations , January 1981 in “Elsevier eBooks”

Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.

research Application of Transglutaminase for Hair Revitalization

3 citations , March 2013 in “Journal of the Society of Cosmetic Scientists of Korea”

Transglutaminase can repair damaged hair, making it stronger and shinier.

Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

research Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree

May 2025 in “Frontiers in Genetics”

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

research Homozygous missense mutation in theLIPHi>gene causing autosomal recessive hypotrichosis simplex in a Chinese patient

2 citations , December 2013 in “Journal of dermatology”

A specific gene mutation causes a rare hair loss condition in a Chinese patient.

research Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study
2 citations , May 2020 in “Journal of the American Academy of Dermatology”

Hair shaft changes may be linked to CCCA, but their role is unclear.

research The Enzymic Derivation of Citrulline Residues from Arginine Residues In Situ during the Biosynthesis of Hair Proteins that are Cross-Linked by Isopeptide Bonds
45 citations , January 1977 in “Advances in experimental medicine and biology”

Hair follicles have an enzyme that converts arginine to citrulline in proteins.

research Protein disulphide isomerase-mediated grafting of cysteine-containing peptides onto over-bleached hair
28 citations , December 2011 in “Biocatalysis and biotransformation”

PDI helps restore over-bleached hair's strength and structure by attaching special peptides.

research 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration
July 2024 in “Journal of Investigative Dermatology”

Inhibiting PDE8A may help treat hair loss by boosting fat cell growth and hair regeneration.

research 9209 Functional Evaluation Of Novel CYP21A2 Variants: Expanding The Genetic Basis Of Non-classic CAH
October 2024 in “Journal of the Endocrine Society”

Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

research Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
250 citations , November 2003 in “The Journal of Cell Biology”

BMP receptor IA is essential for proper hair cell differentiation in mice.

research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules
7 citations , July 2019 in “International Journal of Molecular Sciences”

PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.

research Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS)
2 citations , April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

research Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease
85 citations , March 2008 in “Journal of Cell Science”

The mutation causing Hutchinson-Gilford progeria syndrome leads to severe skin problems and early death in mice.

research Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
59 citations , November 2011 in “Development”

Trps1 is essential for proper hair follicle development.

research The Region Coding for the Helix Termination Motif and the Adjacent Intron 6 of the Human Type I Hair Keratin Gene hHa2 Contains Three Natural, Closely Spaced Polymorphic Sites
6 citations , March 1996 in “Journal of Investigative Dermatology”

research Mechanism of Laccase-assisted Tyrosine Grafting on Keratin using BSA as a Model Protein
October 2021 in “Authorea (Authorea)”

New hair perming method using tyrosine is gentler and can be done with a blow-dryer.

research Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy
12 citations , October 2006

Matriptase imbalance contributes to cancer development and spread.

research Matriptase-2, A Novel Suppressor of Hepcidin.
November 2009 in “Blood”

Matriptase-2 helps control iron levels by suppressing hepcidin, and its deficiency can cause iron-deficiency anemia.

research [Studies on enzyme activities in the hair root in male pattern baldness: glycolytic enzyme, acid hydrolase, transglutaminase and ornithine decarboxylase activities of plucked hair roots].
June 1985 in “PubMed”

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle
1 citations , February 1991 in “Journal of Biological Chemistry”

research The ZIP7 Gene (Slc39a7) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus
195 citations , April 2005 in “Journal of biological chemistry/The Journal of biological chemistry”

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

research β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid
42 citations , June 2019 in “Aging”

3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.

research Expression of NAD+dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle
11 citations , March 2008 in “Experimental Dermatology”

A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

research Immunocytochemical Localization of Peptidylarginine Deiminase Type III, Trichohyalin and Deiminated Trichohyalin in Infant Rat Dorsal Skin Hair Follicle
2 citations , January 2001 in “Biomedical Research”

Trichohyalin and peptidylarginine deiminase type III are found together in rat hair follicles, with trichohyalin being modified after expression.

research Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib
4 citations , November 2020 in “Acta Dermato Venereologica”

Tofacitinib effectively improved severe skin symptoms in a patient with Hypohidrotic Ectodermal Dysplasia.

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