155 citations
,
March 2006 in “The American Journal of Medicine” Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.
120 citations
,
June 2008 in “American Journal of Epidemiology” A simple screening method found that 6.3% of women in a semiurban area in Sri Lanka have polycystic ovary syndrome, with most showing menstrual irregularities.
98 citations
,
April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.
86 citations
,
July 1993 in “Drugs” Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.
85 citations
,
August 2018 in “Psychological Medicine” Women with PCOS are more likely to suffer from depression, anxiety, and stress.
76 citations
,
August 2007 in “Supportive care in cancer” Chemotherapy often causes skin, nail, and hair side effects, significantly impacting quality of life.
76 citations
,
December 1997 in “Fertility and Sterility” Finasteride reduces hair growth better, but spironolactone has more side effects.
72 citations
,
January 2023 in “International Journal of Biological Sciences” Engineered exosomes show promise for improving wound healing but face challenges in clinical use.
70 citations
,
April 2013 in “Endocrine” Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.
68 citations
,
February 2019 in “Urology” Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.
63 citations
,
February 2013 in “Human cell” PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.
59 citations
,
August 2007 in “Clinical Endocrinology” The current methods for diagnosing polycystic ovary syndrome are too vague and may lead to misdiagnosis and problems in research.
57 citations
,
January 1995 in “The American journal of medicine” Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.
56 citations
,
November 2016 in “Aesthetic surgery journal” The document concludes that the effectiveness of platelet rich plasma in aesthetic surgery is unclear due to inconsistent reporting and lack of objective measures in studies.
52 citations
,
September 2020 in “Cell Death and Disease” Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.
52 citations
,
March 2016 in “JAMA dermatology” Patients with PCOS rate their hirsutism higher than clinicians, and these self-ratings are more closely related to their quality of life and risk of depression.
49 citations
,
July 2021 in “Nutrients” Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.
49 citations
,
February 2019 in “The Journal of Clinical Endocrinology and Metabolism” Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.
49 citations
,
May 2018 in “Endocrine” Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.
48 citations
,
January 2018 in “Scientific Reports” Hair analysis can reveal metabolic changes and potential pregnancy complications.
46 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
45 citations
,
February 2019 in “Journal of Affective Disorders” Melatonin improved mental health and metabolism in women with PCOS.
44 citations
,
June 1985 in “Fertility and sterility” Combination drug therapy is effective for hirsutism that doesn't improve with just one medication.
42 citations
,
July 2017 in “Scientific Reports” Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.
38 citations
,
October 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” 5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.
36 citations
,
May 2021 in “Nutrients” Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.
34 citations
,
December 2009 in “The International Journal of Developmental Biology” Too much thymosin beta4 causes weird teeth and more hair growth in mice.
33 citations
,
February 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Platelet-Rich Plasma (PRP) shows promise for treating various skin conditions, but more research is needed to standardize its use.
33 citations
,
January 2018 in “The Journal of Clinical Endocrinology & Metabolism” Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.
33 citations
,
October 2017 in “Drug Safety” SJS/TEN survivors often have severe, overlooked long-term physical problems that are not properly treated after leaving the hospital.