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research 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification

April 2016 in “Journal of Investigative Dermatology”

Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

research Mapping of a novel locus for keratosis follicularis squamosa on chromosome 7p14.3–7p12.1

4 citations , September 2010 in “Journal of Dermatological Science”

A new gene location for Keratosis follicularis squamosa was found on chromosome 7p14.3-7p12.1.

Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Assembly of Hair Keratins in Transfected Epithelial Cells

5 citations , December 1996 in “Biochemical and Biophysical Research Communications”

Mouse hair keratins mHa1 and mHb4 can't form a strong network on their own in cells.

research Genetically separable determinants of hair keratin gene expression

27 citations , January 2000 in “Developmental Dynamics”

Mutations in the Whn gene affect hair keratin gene expression differently.

research Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling

14 citations , June 2022 in “Neuroscience”

research Genome-wide detection of RNA editing events during the hair follicles cycle of Tianzhu white yak

October 2022 in “BMC genomics”

RNA editing significantly affects hair growth and follicle cycling in the Tianzhu white yak.

N6-Methyladenosine Modification of circRNA-ZNF638 Contributes to the Induced Activation of SHF Stem Cells Through miR-361-5p/Wnt5a Axis in Cashmere Goats

research N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats

2 citations , November 2022 in “Animal Bioscience”

A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.

research Keratin expression in the human hair follicle

1 citations , January 1989 in “Springer eBooks”

research 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile

April 2023 in “Journal of Investigative Dermatology”

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

research Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis

10 citations , January 2004 in “Journal of Investigative Dermatology”

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

research P7 p63, K14 and p53 expression in epithelial layers of tumor-distant oral mucosa in patients with oral squamous cell carcinoma

March 2010 in “European Journal of Cancer Supplements”

research KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

4 citations , January 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A faulty KLHL24 gene leads to hair loss by damaging hair follicle stem cells.

research Regulation of Hematopoietic Cell Development and Hair Growth in Mouse Models: Expression Analysis of Tudor-SN and Polyamine-Regulated Proteins

January 2013 in “Tampere University Institutional Repository (Tampere University)”

Tudor-SN is important for immune cells, and polyamines can promote hair growth.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research Molecular modeling and structural characterization of a high glycine–tyrosine hair keratin associated protein

16 citations , January 2017 in “Physical chemistry chemical physics/PCCP. Physical chemistry chemical physics”

The 3D structure of a key hair protein was modeled, revealing specific helical structures and stabilization features.

research A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb

5 citations , June 2008 in “British Journal of Dermatology”

research A 4kb Fragment of the Desmocollin 3 Promoter Directs Reporter Gene Expression to Parakeratotic Epidermis and Primary Hair Follicles

1 citations , July 2006 in “Journal of Investigative Dermatology”

A 4kb fragment of the desmocollin 3 promoter targets gene expression to specific skin and hair follicle areas.

research Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype

75 citations , April 2000 in “Developmental Dynamics”

Whn is essential for hair growth, and its malfunction causes hair loss.

research The Transcriptomics and Epigenomics of Hair Follicles

January 2024 in “Updates in clinical dermatology”

research p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

p63 controls Satb1 to help skin develop properly.

research Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles

34 citations , October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis”

research TRPS1 haploinsufficiency results in increased STAT3 and SOX9 mRNA expression in hair follicles in trichorhinophalangeal syndrome

2 citations , September 2016 in “Journal of Dermatological Science”

Reduced TRPS1 leads to increased STAT3 and SOX9 in hair follicles, affecting hair growth.

research The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin

8 citations , January 2013 in “genesis”

Zfp157 is active in many mouse tissues during development and in specific adult cells.

research Influence of TRPV3 mutation on hair growth cycle in mice

59 citations , September 2007 in “Biochemical and Biophysical Research Communications”

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

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