Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.
71 citations
,
October 2017 in “Journal of Investigative Dermatology” PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.
26 citations
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January 2018 in “Annals of dermatology/Annals of Dermatology” Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
4 citations
,
January 2018 in “Advances in Experimental Medicine and Biology” The document concludes that hair follicles have a complex environment and our understanding of it is growing, but there are limitations when applying animal study findings to humans.
132 citations
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August 2008 in “Development” Dlx3 is essential for hair growth and regeneration.
64 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Human stem cells can help form hair follicles in mice.
52 citations
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October 2005 in “Journal of Investigative Dermatology” Hair follicle stem cells have greater longevity and adhesion, while transit-amplifying cells are more mobile.
51 citations
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April 2013 in “Journal of Investigative Dermatology” Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.
23 citations
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May 2019 in “Stem cell research & therapy” iPSC-derived stem cells on a special membrane can help repair full-thickness skin defects.
2 citations
,
June 2001 in “American Journal of Pathology” The document concludes that understanding how hair follicles naturally die and regenerate is important for insights into organ development and could impact health and disease treatment.
32 citations
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August 2006 in “Archives of Dermatological Research” Dermal papilla cells can help regrow hair follicles.
1 citations
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January 2012 in “International journal of trichology” Sheep hair follicle cells can grow a lot but need the dermal papilla to do so.
October 2025 in “Cell Reports” Regulatory T cells help hair growth by using the Cxcr4-Cxcl12 pathway.
80 citations
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September 2007 in “Cell Cycle” Stem cells in hair follicles can become various cell types, including neurons.
2 citations
,
August 2012 in “Cell Stem Cell” The study showed that some hair follicle stem cells wake up to grow hair while others stay asleep, and that the environment around them is important for hair growth.
4 citations
,
February 2013 in “PubMed” A3 antibody helps identify key cells in rat hair follicle development.
1 citations
,
July 2023 in “Communications biology” Removing Mediator 1 from certain mouse cells causes teeth to grow hair instead of enamel.
1 citations
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January 2022 in “Cell Biology International” Changing CDK4 levels affects the number of stem cells in mouse hair follicles.
December 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The conclusion is that the dermal papilla is crucial for hair follicle regrowth, and hair follicles undergo significant structural changes in addition to cell division during regeneration.
December 2013 in “Research Portal (King's College London)” Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.
61 citations
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January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
1 citations
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July 2011 in “The Egyptian Journal of Anatomy” Both TCA and GA peels effectively improved skin thickness and collagen without significant differences.
April 2018 in “Journal of Investigative Dermatology” A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.
April 2018 in “Journal of Investigative Dermatology” Macrophages are more involved in Lichen planopilaris than in Frontal fibrosing alopecia.
April 2018 in “Journal of Investigative Dermatology” Different types of stem cells in the skin contribute to the variety of melanoma forms.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
479 citations
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June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
159 citations
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January 2006 in “BMC Cell Biology” Wnt signaling can improve skin healing by promoting epithelial growth.
8 citations
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September 2002 in “Genes to Cells” Killing specific cells in hair follicles can lead to hair growth problems in mice.
1 citations
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January 2013 in “Journal of Investigative Dermatology” The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.