January 2012 in “Methods in pharmacology and toxicology” TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
Newer retinoid drugs are effective for skin conditions but have significant side effects.
82 citations
,
May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
23 citations
,
September 2018 in “Journal of Investigative Dermatology” A hydrogel made from pig fat helps wounds heal faster by regenerating skin fat cells.
15 citations
,
October 2020 in “European journal of pharmaceutics and biopharmaceutics” Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.
2 citations
,
July 2025 in “Journal of Plastic Reconstructive & Aesthetic Surgery” Hair follicles can improve wound healing and reduce scarring.
January 2023 in “Operative Techniques in Otolaryngology-Head and Neck Surgery” Hair transplants help transgender patients look more like their gender identity, with different procedures for trans women and men.
14 citations
,
September 2010 in “Annals of Plastic Surgery” Hair restoration has evolved from surgery to drugs to potential gene therapy, with improved results and ongoing research driven by high demand.
1 citations
,
November 2022 in “Experimental cell research” Prostaglandin E2 collagen matrix may help stimulate hair growth.
222 citations
,
October 1993 in “Journal of The American Academy of Dermatology” Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.
130 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
118 citations
,
December 2003 in “Mechanisms of Ageing and Development” Thymosin β4 helps heal wounds, grow hair, and improve blood vessel formation.
89 citations
,
November 2017 in “Journal of Cellular Physiology” The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.
86 citations
,
May 2008 in “Cytokine & growth factor reviews” TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.
71 citations
,
June 2005 in “Journal of Investigative Dermatology” PAD enzymes play a key role in hair growth and structure.
69 citations
,
April 2005 in “Forensic Science International” Degraded hair shafts resist contamination and can be easily cleaned.
48 citations
,
February 2010 in “Molecular biology reports” KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.
33 citations
,
January 2018 in “International Journal of Biological Sciences” CRISPR-Cas9 can successfully edit genes in large mammals like Cashmere goats.
29 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
29 citations
,
October 2011 in “British Journal of Dermatology” Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.
28 citations
,
August 1992 in “Differentiation” A new pair of mouse keratins, 65 kD and 48 kD, are found in specific skin areas and are linked to a unique skin differentiation type.
22 citations
,
September 2001 in “Journal of Investigative Dermatology” S100A8 and S100A9 proteins help form hair shafts during growth.
18 citations
,
February 1992 in “Molecular Biology Reports” A specific type II hair keratin was identified and found in hair cortex and tongue cells.
10 citations
,
November 2008 in “Veterinary Dermatology” The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.
4 citations
,
June 2005 in “British Journal of Dermatology” People often underestimate hair loss severity, with fewer seeking treatment, and it's more distressing for women.
4 citations
,
January 2004 in “Biological and Pharmaceutical Bulletin” AgK114 protein helps in hamster skin injury recovery.
3 citations
,
October 2018 in “Archives of Dermatological Research” Applying InlB321/15 to wounds sped up healing in mice.
1 citations
,
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The fer-ts mutation in plants prevents root hair growth at high temperatures.
November 2013 in “Journal of clinical & experimental dermatology research” Using urinary bladder matrix and platelet rich plasma can effectively treat transplant scars and prevent hair loss.
19 citations
,
February 2008 in “Facial Plastic Surgery” The article concludes that microvascular free flaps, especially the latissimus dorsi flap, are recommended for large scalp reconstructions, and hair transplantation offers high survival rates and excellent aesthetic results.