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GlossaryHair Follicle Atrophy

gradual shrinking and weakening of hair-producing structures

Hair follicle atrophy refers to the gradual shrinking and weakening of hair follicles, which are the tiny structures in the skin that produce hair. This process can lead to thinner hair or even hair loss, as the follicles become less capable of supporting healthy hair growth. It can be caused by factors such as aging, hormonal changes, or certain medical conditions.

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Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice

research Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice

48 citations , May 2015 in “NPJ microgravity”

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research Nestin-Expressing Stem Cells from the Hair Follicle Can Differentiate Into Motor Neurons and Reduce Muscle Atrophy after Transplantation to Injured Nerves

7 citations , September 2013 in “Tissue engineering. Part A”

Hair follicle stem cells can become motor neurons and reduce muscle loss after nerve injury.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

research Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle

4 citations , December 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

research Endogenous retinoids in the hair follicle and sebaceous gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station

14 citations , March 2016 in “PloS one”

Spaceflight changes how genes work in astronauts' hair follicles, possibly affecting hair growth.

research Leptomeningeal angiomatosis accompanied by hair follicle nevus

11 citations , May 1998 in “Child's nervous system”

A baby had a rare condition with abnormal blood vessels in the brain and unusual skin and hair growth, possibly a new syndrome.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide

2 citations , November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Aberrant Wnt signalling induces comedo-like changes in the upper hair follicle

1 citations , October 2020 in “Research Square (Research Square)”

Abnormal Wnt signaling in hair follicle stem cells can lead to acne-like cysts.

research Histomorphological changes of the skin and hair follicles caused by different diseases in dogs with alopecia

January 2016 in “Lithuanian University of Health Sciences”

Different diseases cause specific skin and hair follicle changes in dogs with alopecia.

Beta-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

research β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

February 2024 in “Molecules/Molecules online/Molecules annual”

NMN could potentially treat hair loss by reducing oxidative stress and improving cell health.

research Adenohypophysitis Associated with Sebaceous Gland Atrophy in a Dog

11 citations , July 1991 in “Veterinary Pathology”

A dog had a rare skin condition linked to gland and pituitary issues.

research Eyebrow reconstruction in dormant keratosis pilaris atrophicans

6 citations , July 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

Eyebrow reconstruction using hair follicle grafts was successful in a man with a benign hereditary disorder affecting his eyebrows.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Does Active Form of Vitamin D3 Prevent Hair Follicles from Radiation Toxicity?

research 635 poster Does active form of vitamin D3 prevent hair follicules from radiation toxicity?

October 2004 in “Radiotherapy and oncology”

Active vitamin D3 might protect hair follicles from radiation damage.

research Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases

15 citations , December 2011 in “Journal of the European Academy of Dermatology and Venereology”

Hair loss in systemic lupus erythematosus patients is unique and improves with treatment.

research Updated Management of Atrophic Post Acne Scars: Review Article

October 2021 in “The Egyptian Journal of Hospital Medicine ”

Combination therapies work better than single treatments for atrophic acne scars.

Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans

47 citations , July 2005 in “British Journal of Dermatology”

Topical vitamin D3 does not prevent hair loss from chemotherapy.

Efficacy and Safety of a New Topical Hair Loss Lotion Containing Oleanolic Acid, Apigenin, Biotinyl Tripeptide-1, Diaminopyrimidine Oxide, Adenosine, Biotin, and Ginkgo Biloba in Patients with Androgenetic Alopecia and Telogen Effluvium: A Six-Month Open-Label Prospective Clinical Study

research Efficacy and Safety of a New Topical Hair Loss-Lotion Containing Oleanolic Acid, Apigenin, Biotinyl Tripeptide-1, Diaminopyrimidine Oxide, Adenosine, Biotin and Ginkgo biloba in Patients with Androgenetic Alopecia and Telogen effluvium: A Six-month Open-Label Prospective Clinical Study

1 citations , January 2018 in “Journal of cosmetology & trichology”

Hair loss lotion with specific ingredients effectively improves hair growth and thickness safely.

research Hair Removal in Darker Skin Types Using Light-Based Devices

1 citations , January 2009 in “Elsevier eBooks”

Laser hair removal can be effective for darker skin but requires careful use to avoid side effects.

research Ulerythema ophryogenes (keratosis pilaris atrophicans faciei).

September 2016 in “European Journal of Pediatric Dermatology/PD. European journal of pediatric dermatology”

Ulerythema ophryogenes causes hair thinning and inflammation, with limited treatment options.

research Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars

February 2024 in “Australasian journal of dermatology”

Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.

Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

research Histopathological insights into hair loss in Cronkhite-Canada syndrome: Diffuse anagen-telogen conversion precedes clinical hair loss progression

16 citations , May 2013 in “Australasian Journal of Dermatology”

Hair loss in Cronkhite-Canada syndrome is reversible by treating the gut issues and doesn't need steroid treatment for the hair itself.

research Changes in murine hair with dietary selenium excess or deficiency

6 citations , March 2011 in “Experimental Dermatology”

Too much or too little selenium in the diet can cause hair loss and graying in mice.

research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis

18 citations , August 2019 in “Clinical breast cancer”

Local hormonal treatment for vulvovaginal atrophy is likely safe for women with estrogen receptor-positive breast cancer on aromatase inhibitors.

research Dermatitis cruris pustulosa et atrophicans

11 citations , January 2009 in “Indian journal of dermatology, venereology, and leprology”

DCPA is a chronic skin condition affecting the lower limbs, mainly in men, with unclear causes and treatments that often don't work well.

research Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.

August 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Overexpression of a specific receptor in mice skin causes skin thinning, early skin barrier formation, eye issues, and hair loss.

research The Effect of Zinc Sulphate in The Prevention of Radiation-induced Dermatitis

57 citations , January 2004 in “Journal of Radiation Research”

Zinc sulphate may help reduce skin damage from radiation therapy.

Alopecia Neoplastica Due to Gastric Adenocarcinoma Metastasis to the Scalp, Presenting as Alopecia: A Case Report and Literature Review

research Alopecia Neoplastica due to Gastric Adenocarcinoma Metastasis to the Scalp, Presenting as Alopecia: A Case Report and Literature Review

26 citations , January 2014 in “Annals of Dermatology”

Hair loss can occur when stomach cancer spreads to the scalp.